Pathological assessment of Nigella sativa oil and its chitosan loaded nanoparticles on experimental hepatic cystic echinoncoccosis | ||
| Parasitologists United Journal | ||
| Article 9, Volume 14, Issue 1, April 2021, Pages 58-62 PDF (500.48 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/puj.2021.59854.1105 | ||
| Authors | ||
| Shereen Kishik1; Ibrahim Nagati1; Ibrahim Ali2; Nagwa Aly1; Maha Fawzy1; Hemat Ali* 1 | ||
| 1Departments of Parasitology , Faculty of Medicine, Benha University, Benha | ||
| 2Immunoparasitology , Theodor Bilharz Research Institute, Imbaba, Giza, Egypt | ||
| Abstract | ||
| Background: Hydatid cyst is one of the most common cysts detected in the liver. Surgery is the preferred approach in treatment, but surgery may have serious complications as anaphylaxis, implantation of scolices, and formation of secondary cysts. Medical treatment with surgery decreases probability of these complications. Objectives: To evaluate the efficacy of Nigella sativa oil (NSO), Albendazole (ABZ) and chitosan nanoparticles (CS NPs) as drug carrier to increase the efficacy of ABZ and NSO. Material and Methods: Mice were infected with E. granulosus scolices and classified according to drugs schedule into five groups (G): G (3) was infected and treated with ABZ; G (4) was infected and treated with NSO; G (5) was infected and treated with NSO and ABZ; G (6) was infected and treated with ABZ loaded on CS NPs, G (7) was infected and treated with NSO loaded on CS NPs. Two control groups were assigned: G (1) was non infected non treated and G (2) was infected non treated. Four months post infection, mice were sacrificed and collected livers of each group were sectioned for histopathology. Results: Histopathological studies revealed that groups treated with drugs loaded on CS NPs contained no hydatid cysts with improvement in the degree of inflammation, necrosis, and congestion of hepatic tissue. Conclusion: It was concluded that the best curative effect was observed in groups treated with drugs loaded on CS NPs. | ||
| Keywords | ||
| chitosan nanoparticles; hepatic tissue; histopathological evaluation; hydatid cyst; Nigella sativa oil | ||
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