Gardouh, A., Sayed, H., Ghorab, M., Abdel-Rahman, S. (2010). Preparation and characterization of solid lipid nanoparticles II. Effect of viscosity, method of preparation and homogenization speed on Physical Characteristics of Solid Lipid Nanoparticles. test, 19(2), 5-19. doi: 10.21608/zjps.2010.167378
Ahmed Gardouh; Hussein Sayed; Mamdouh Ghorab; Shaded Abdel-Rahman. "Preparation and characterization of solid lipid nanoparticles II. Effect of viscosity, method of preparation and homogenization speed on Physical Characteristics of Solid Lipid Nanoparticles". test, 19, 2, 2010, 5-19. doi: 10.21608/zjps.2010.167378
Gardouh, A., Sayed, H., Ghorab, M., Abdel-Rahman, S. (2010). 'Preparation and characterization of solid lipid nanoparticles II. Effect of viscosity, method of preparation and homogenization speed on Physical Characteristics of Solid Lipid Nanoparticles', test, 19(2), pp. 5-19. doi: 10.21608/zjps.2010.167378
Gardouh, A., Sayed, H., Ghorab, M., Abdel-Rahman, S. Preparation and characterization of solid lipid nanoparticles II. Effect of viscosity, method of preparation and homogenization speed on Physical Characteristics of Solid Lipid Nanoparticles. test, 2010; 19(2): 5-19. doi: 10.21608/zjps.2010.167378

Preparation and characterization of solid lipid nanoparticles II. Effect of viscosity, method of preparation and homogenization speed on Physical Characteristics of Solid Lipid Nanoparticles

Zagazig Journal of Pharmaceutical Sciences
Article 2, Volume 19, Issue 2, December 2010, Pages 5-19    PDF (2.94 M)
Document Type: Original Article
DOI: 10.21608/zjps.2010.167378
Authors
Ahmed Gardouh* 1; Hussein Sayed2; Mamdouh Ghorab2; Shaded Abdel-Rahman2
1Department of pharmaceutics and industrial pharmacy, faculty of pharmacy, Suez Canal University, Ismailia, Egypt.
2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Abstract
The objective of this study was to determine the best conditions to formulate solid lipid Nanoparticles using Glyceryl  monostearate as lipid matrix which has advantage to be biocompatible and easily degraded in vivo. Different formulation factors were studied including effect of viscosity, method of manufacture and homogenization speed. It was found that method of emulsion solvent injection technique produced smaller particles size than that of the hot homogenization technique for both Tween 20 and Tween 80. The effect of viscosity was prominent with high viscosity value obtained through use of 50 % glycerol as viscosity enhancer. According to homogenization speed, it was found that increasing homogenization speed from 6,000 rpm to 12,000 rpm produced smaller solid lipid nanoparticles with small polydispersity index and homogenous distribution of particle size distribution.
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