Hegazy, M., Elshahed, M., Toubar, S., Helmy, M. (2018). Efficient Processing of Single and Multiple Spectral Variables for Resolution and Quantitation of Paracetamol, Chlorzoxazone and Diclofenac. test, 2(4), 269-282. doi: 10.21608/aprh.2018.5165.1064
Maha Hegazy; Mona Elshahed; Safaa Toubar; Marwa Helmy. "Efficient Processing of Single and Multiple Spectral Variables for Resolution and Quantitation of Paracetamol, Chlorzoxazone and Diclofenac". test, 2, 4, 2018, 269-282. doi: 10.21608/aprh.2018.5165.1064
Hegazy, M., Elshahed, M., Toubar, S., Helmy, M. (2018). 'Efficient Processing of Single and Multiple Spectral Variables for Resolution and Quantitation of Paracetamol, Chlorzoxazone and Diclofenac', test, 2(4), pp. 269-282. doi: 10.21608/aprh.2018.5165.1064
Hegazy, M., Elshahed, M., Toubar, S., Helmy, M. Efficient Processing of Single and Multiple Spectral Variables for Resolution and Quantitation of Paracetamol, Chlorzoxazone and Diclofenac. test, 2018; 2(4): 269-282. doi: 10.21608/aprh.2018.5165.1064

Efficient Processing of Single and Multiple Spectral Variables for Resolution and Quantitation of Paracetamol, Chlorzoxazone and Diclofenac

Journal of Advanced Pharmacy Research
Article 5, Volume 2, Issue 4, October 2018, Pages 269-282    PDF (524.21 K)
Document Type: Research Article
DOI: 10.21608/aprh.2018.5165.1064
Authors
Maha Hegazy1; Mona Elshahed2; Safaa Toubar2; Marwa Helmy* 2
1Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt.
2Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, EinHelwan, 11795, Cairo, Egypt
Abstract
Objectives: The main aim of this study is to apply smart, simple, rapid and accurate methods for simultaneous determination of Paracetamol (PAR), Chlorzoxazone (CXZ) and Diclofenac potassium (DIC), in their bulk powder and tablet dosage form. Methods: Potent processing methods were used which were based on the application of continuous wavelet transform (CWT) and Savitsky–Golay derivatization (SAVGOL) as univariate spectrophotometric methods, partial least squares (PLS) and synergy interval partial least squares (siPLS) as multivariate methods. Results: PAR, CXZ and DIC were determined in the concentration ranges of 2–30, 2–50 and 2–30 μg/mL, respectively. The regressing and validation parameters of the proposed methods revealed the efficiency of the methods.  The results obtained for the analysis of those drugs by the proposed methods were statistically compared to those obtained by applying a reported high performance liquid chromatographic method. Statistical comparison was done, and no significant difference was found between the proposed methods and the reported one. Conclusion: Successful determination of ternary mixture containing PAR, CXZ and DIC was achieved with no need for tedious sample separation or pre-treatment derivatization which is considered a great benefit in quality control laboratories.
Keywords
Paracetamol; Chlorzoxazone; Diclofenac; CWT; SAVGOL; PLS; siPLS
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