Assessment of protective potential of Quercitin against carbendazim-induced testicular damage in male rats | ||
| Benha Veterinary Medical Journal | ||
| Article 28, Volume 34, Issue 2, June 2018, Pages 305-320 PDF (767.31 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bvmj.2018.168346 | ||
| Authors | ||
| Omayma Abou Zaid1; Ahmed El saed2; Abeer Elbatal1 | ||
| 1Department of Biochemistry, Faculty of Veterinary Medicine, Benha University | ||
| 2Department of Histology, Faculty of Veterinary Medicine, Zagazig University | ||
| Abstract | ||
| Quercetin (Q) is a common flavonoid, with potent anti‑inflammatory and antioxidant activities. However, its protective role against the hazards of fungicides has been poorly studied. Therefore, the present work aimed at determining the ameliorative potential of Q against testicular damage induced by carbendazim (CBZ) in male rats. In CBZ‑induced testicular damage rats treated with quercetin, it was demonstrated that the activities of the antioxidant enzymes superoxide dismutase (SOD) and glutathione content (GSH) were increased, malondialdehyde (MDA) was inhibited, and interleukin (IL)‑1β, IL-6, Tumor necrosis factor-α (TNF-α) were suppressed. Quercetin additionally enhanced testosterone and cyclic guanine monophosphate (cGMP) levels. These results suggested that the protective role of quercetin prevents CBZ‑induced testicular damage through the free radical scavenging activities, preventing pro-inflammatory cytokine production and improving the male reproductive markers. | ||
| Keywords | ||
| Quercetin; CBZ; cGMP; Testicular damage; Oxidative stress | ||
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