MINERAL AND HORMONAL CHANGES AFTER ADMINISTRATION OF SOME ANTIRHEUMATICS TO ADULT RATS | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 5, Issue 2, December 1996, Pages 1-3 PDF (1.6 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjps.1996.169712 | ||
| Authors | ||
| Mohamed Hassan* 1; Abdel -Alim Abdel-Alim2 | ||
| 1Department of Physiology and Biochemistry, Faculty of Veterinary Medicine, Zagazig University | ||
| 2Department of Pharmacology Faculty of Veterinary Medicine, Zagazig University, Egypt | ||
| Abstract | ||
| Dexamethasone sodium phosphate (0.13 mg/kg b. wt) and diclofenac sodium (6.7 mg/kg kg b.wt.) were injected intramuscularly day after day for two weeks to two groups of mature male rats respectively. After the end of the experiment, all rats of the treated and control groups were killed and blood samples were collected. Testosterone, corticosteroids prolactin, sodium and potassium levels were determined in the serum.Dexamethasone and diclofenac sodium significantly decreased testosterone level whereas, they elicited a significant increase in the levels of corticosteroids and prolactin. Serum sodium and potassium showed a significant increase and decrease as a result of treatment with dexamethasone and diclofenac respectively. | ||
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