NEW CONDENSED PYRIMIDINES AS POTENTIAL ΑNALGETICS | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Article 1, Volume 1, Issue 2, December 1992, Pages 85-93 PDF (4.14 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjps.1992.169730 | ||
| Author | ||
| El-Sayed Lashine* | ||
| Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt | ||
| Abstract | ||
| New O-aminonitriles (enaminonitriles) namely, pyrimido[1,6-a] indole were prepared by addition of 2-dicyanome thylidinoindoline-obtained from oxindole- to various isothiocyanates. The obtained enaminonitriles were acylated using chloroacetylchloride yielding methylchloride derivatives of the condensed pyrimidines, pyrimido (4,5 :4,5] pyrimido[1,6-a] indole. The chlorine atom was substituted by different amines or condensed with thiourea and the formed salts were hydrolyzed to give mercaptoalkyl compounds. Some of the prepared compounds were tested for their analgetic activities. | ||
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