Hepatitis C Virus: From Liver to Bone Disease, There are Multiple Stations | ||
| Afro-Egyptian Journal of Infectious and Endemic Diseases | ||
| Editorial, Volume 4, Issue 3, September 2014, Pages 114-116 PDF (144.45 K) | ||
| DOI: 10.21608/aeji.2014.17183 | ||
| Authors | ||
| Mohamed I Radwan; Ehab M Darweish | ||
| Tropical Medicine Department, Faculty of Medicine, Zagazig University, Egypt | ||
| Abstract | ||
| Osteoporosis is defined as a "progressive systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture" Common fractures are vertebral compression fractures, fractures of the distal radius, and proximal femur . World Health Organization defines osteoporosis as a bone mineral density (BMD) measurement of 2.5 standard deviations or more below the population mean BMD of sex-matched young adults, i.e., a t-score of ≤−2.5. The term "established osteoporosis" includes the presence of a fragility fracture . Osteoporosis can result in spontaneous or low trauma fractures in the patients, adversely affecting morbidity, quality of life. The prevalence of osteoporosis associated fracture ranges from 5% to 20% . Osteoporosis and osteopenia are well known complications in patients with chronic liver disease. Its prevalence varies considerably. It ranges from 12 to 55% according to many factors including patient selection, diagnostic criteria, underlying liver disease and it also increases with the increased severity of the liver disease defined as advanced Child-Pugh score . Osteoporosis is a risk factor for development of fractures, which may be a source of morbidity in patients already debilitated by chronic liver disease. Prevention of morbidity of hepatic osteodystrophy is to identify those patients who are predisposed to development of osteopenia and osteoporosis | ||
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