Mohamed rashid, A., Elsayed sheir, R., Mohamed Ahmed, T., Mohamed Farhan, H. (2021). Evaluation of NPHS2 gene polymorphism (R229Q) in chronic kidney disease patients. test, 2(2), 20-30. doi: 10.21608/ejmr.2021.174556
Ahmed Mohamed rashid; Rania Elsayed sheir; Thoraya Mohamed Ahmed; Hanan Mohamed Farhan. "Evaluation of NPHS2 gene polymorphism (R229Q) in chronic kidney disease patients". test, 2, 2, 2021, 20-30. doi: 10.21608/ejmr.2021.174556
Mohamed rashid, A., Elsayed sheir, R., Mohamed Ahmed, T., Mohamed Farhan, H. (2021). 'Evaluation of NPHS2 gene polymorphism (R229Q) in chronic kidney disease patients', test, 2(2), pp. 20-30. doi: 10.21608/ejmr.2021.174556
Mohamed rashid, A., Elsayed sheir, R., Mohamed Ahmed, T., Mohamed Farhan, H. Evaluation of NPHS2 gene polymorphism (R229Q) in chronic kidney disease patients. test, 2021; 2(2): 20-30. doi: 10.21608/ejmr.2021.174556

Evaluation of NPHS2 gene polymorphism (R229Q) in chronic kidney disease patients

Egyptian Journal of Medical Research
Article 3, Volume 2, Issue 2 - Serial Number 1, June 2021, Pages 20-30    PDF (503.27 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2021.174556
Authors
Ahmed Mohamed rashid1; Rania Elsayed sheir1; Thoraya Mohamed Ahmed1; Hanan Mohamed Farhan2
1Internal medicine department, Faculty of Medicine, Beni-Suef University, Egypt
2Chemical and clinical pathology department, Faculty of Medicine, Beni-Suef University, Egypt
Abstract
The aim of this study was to evaluate the role of nephrotic syndrome 2 (NPHS2) gene polymorphism (R229Q) in chronic kidney disease which has unclear etiology.
This study was conducted on 80 CKD patients compared with 40 age and sex matched normal volunteers acting as a control group. All of them underwent renal function tests and were assessed for the presence of NPHS2 gene polymorphism. We noticed that (R229Q) is a common variant in Egyptian population. Its concentration was (62.5%) in CKD patients and (55%) in control group. There was no significant difference with p-value > 0.05 between patients and control groups as regards to NPHS2 genotypes and alleles.
Keywords
Chronic kidney disease ˗ NPHS2 gene polymorphism
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