Kotb, E., Serag, W., Elshaarawy, R., Hafez, H., Elkhayat, Z. (2021). The protective role of Gallic acid in Cisplatin nephrotoxicity. test, 2(1), 48-52. doi: 10.21608/fsrt.2021.77860.1040
Ebtesam Samir Kotb; Waleed Mohamed Serag; Reda Fathy Elshaarawy; Hani Sayed Hafez; Zakaria Elkhayat. "The protective role of Gallic acid in Cisplatin nephrotoxicity". test, 2, 1, 2021, 48-52. doi: 10.21608/fsrt.2021.77860.1040
Kotb, E., Serag, W., Elshaarawy, R., Hafez, H., Elkhayat, Z. (2021). 'The protective role of Gallic acid in Cisplatin nephrotoxicity', test, 2(1), pp. 48-52. doi: 10.21608/fsrt.2021.77860.1040
Kotb, E., Serag, W., Elshaarawy, R., Hafez, H., Elkhayat, Z. The protective role of Gallic acid in Cisplatin nephrotoxicity. test, 2021; 2(1): 48-52. doi: 10.21608/fsrt.2021.77860.1040

The protective role of Gallic acid in Cisplatin nephrotoxicity

Frontiers in Scientific Research and Technology
Article 8, Volume 2, Issue 1, 2021, Pages 48-52    PDF (422.43 K)
Document Type: Original Article
DOI: 10.21608/fsrt.2021.77860.1040
Authors
Ebtesam Samir Kotb* 1; Waleed Mohamed Serag2; Reda Fathy Elshaarawy3; Hani Sayed Hafez4; Zakaria Elkhayat5
1Chemistry department (biochemistry), Faculty of science; Suez University; Suez - Egypt
2Chemistry department (biochemistry), Faculty of Science – Suez University – Suez - Egypt
3Chemistry department, Faculty of Science – Suez University – Suez - Egypt
4Zoology Department, Faculty of Science, Suez University, Suez, Egypt.
5Medical Biochemistry, National Research Center, Giza, Egypt
Abstract
Background: Nephrotoxicity is considered one of the most serious and dose-limiting factors for restricting clinical use of Cisplatin and anticancer efficacy. Gallic acid is a non-toxic substance that has a wide range of therapeutic roles with high antioxidant activity. So, the present study aims to investigate the concurrent protective action of Gallic acid against inflammatory and oxidative damage caused by Cisplatin in rat kidneys. Material and methods: Thirty-two male albino rats were classified into four groups, eight per each as follows: Group 1 (Normal Control group): without treatment. Group 2 (Gallic acid group): healthy rats were given Gallic acid. Group 3 (Cisplatin group): healthy rats were injected with cisplatin. Group 4 (Gallic acid + Cisplatin) treated group. Kidney functions, Paraoxonase-1, and inflammatory cytokines such as Tumor Necrosis Factor α, respectively were determined. Results: Cisplatin was induced kidney damage with a high significance (P <0.001) regarding kidney function tests and the group of Cisplatin + Gallic acid demonstrated a broad range in the prevention and/or management of kidney damage with a high significance (P <0.001) compared to cisplatin group. Conclusion: Gallic acid has a protective role against kidney dysfunction and renal damage in Cisplatin therapy.
Keywords
Nephrotoxicity; Cisplatin; DNA damage; Gallic acid; Antioxidant
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