Potentiometric Determination of Fexofenadine Hydrochloride Drug by Fabrication of Liquid Membrane Electrodes | ||
| Egyptian Journal of Chemistry | ||
| Article 15, Volume 64, Issue 11, November 2021, Pages 6293-6300 PDF (455.46 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.76542.3749 | ||
| Authors | ||
| Amina Mohsen Abass* 1; Omar Salih Hassan2; Haider TH.Salim AL Rikabi3; Ahmed Ahmed4 | ||
| 1Department of Chemistry,College of Sciences,Al-Nahrain University | ||
| 2Department of Chemistry, College of Education for Pure Science, Tikrit University, Tikrit Iraq. | ||
| 3Department of Electrical Engineering, College of Engineering ,Wasit University , Wasit, Iraq. | ||
| 4Department of Chemistry, College of Science, Al-Nahrain University. Baghdad, Al-Jaderia ,Iraq. | ||
| Abstract | ||
| This paper presents a study in the electrochemical methods for the preparation three new electrodes of Fexofenadine hydrochloride in a polymeric membrane. The first electrode was prepared from ion pair: molybdophosphoric acid reagent and fexofenadine cation with Di-n-butyl phthalate (DBPH), the subsequent electrode was prepared with O-Nitro phenyl octyl ether( NPOE) and the third electrode was set up by Tri-n-butyl phthalate (TBP), respectively as a plasticizers for determination of Fexofenadine hydrochloride drug. Two electrodes indicated a Nernstian response with a slope of [57.01, 56.70] mV.decade−1 for the first and second electrodes individually, with detection limits 5.6×10-6 mole.L-1 for first electrode and 3.5×10-6 mole.L-1 for second electrode and the third electrode was gave a non Nernstain response equivalent to 14.30 mV.decade−1. The electrodes work adequately over pH range (2.0-4.5),(2.5-4.0) and (2.0- 4.0) for Fexofenadine hydrochloride electrodes. The impact of interfering species was insignificant as demonstrated by selectivity coefficient values. The viability of the electrodes proceeded in a timeframe (41,36,and 13) days. The recommended electrodes were successfully used for the determination of Fexofenadine hydrochloride in pure form and pharmaceuticals preparations. This work arrived at excellent outcomes as far as the linearity, exactness, selectivity, and accuracy of the methods. | ||
| Keywords | ||
| PVC electrodes; Ion-Selective Electrodes; Fexofenadine Hydrochloride; Sensors; Electrochemistry | ||
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