Alpha-fetoprotein as a differential marker between bladder cancer and Schistosomiasis among Egyptian patients | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 6, Volume 30, Issue 1, January 2008, Pages 62-69 PDF (1.43 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2008.17653 | ||
| Authors | ||
| Maghraby A.S1; Samia A. Ahmed2; Ayman M. Metwally3; Khalid H4 | ||
| 1Therapeutic Chemistry Department National Research Center, Dokki, Cairo. Infectious Diseases and Immunology group, Center of Excellence for Advanced Studies | ||
| 2Therapeutic Chemistry Department National Research Center, Dokki, Cairo. | ||
| 3Technology of Medical Laboratory Department, College of Applied Medical Sciences, Misr University For Science and Technology, 6th of October, Egyp | ||
| 4National Cancer Institute, Cairo | ||
| Abstract | ||
| Introduction: Schistosomiasis is considered as a widespread problem that affects Egyptians at different ages (WHO, 1993). It is well known that the high incidence of bladder carcinoma in schistosomal patients also represents a great risk to Egyptian society. Objective: This study represents a survey on the changes which took place in Alpha- Fetoprotein (AFP) levels as a differential marker among Egyptian patients suffering from urinary bilharzial infection and bladder cancer. Methodology: A partial study was carried out on four post-operative patients and followed up for sixty three days after chemotherapeutic treatment using immunoenzymatic mediated assay. Results: It was found that bladder cancer leads to obvious significant increase in AFP levels, while schistosomal infection causes a non-significant decrease as compared to healthy control. Although the combination between schistosomal infection and cancer leads to a significant decrease in AFP level compared to non bilharzial cancer cases, there was no significant correlation with healthy cases. Conclusion: It should be pointed out that the somewhat constant level of AFP in the sera of all patients was due to chemotherapeutic treatment. Also, it can be noticed that there is a significant positive correlation with progress of cancer grades. | ||
| Keywords | ||
| alpha-fetoprotein; schistosomal infection; urinary bilharzial infection and bladder cancer | ||
|
Statistics Article View: 153 PDF Download: 465 |
||
