The Role Of Melatonin In Aluminium Induced Genotoxicity In Female Albino Rats | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 6, Volume 28, Issue 1, July 2007, Pages 355-362 PDF (302.81 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2007.17667 | ||
| Author | ||
| Zeinab E .Hanafy | ||
| Department of Zoology, Faculty of Science (Girls), Al-Azhar University | ||
| Abstract | ||
| Aim of the work, In spite of the wide range of use of aluminium. With the increasing awareness of possible health hazards associated with their use, more attention have been focused on their biological and biochemical activity. Aluminium salts are used as the active antiperspirant in under cosmetics, but the effects of widespread, long term and increasing use remain unknown. Aluminium is known to have genotoxic profile, capable of causing both DNA alterations and epigenetic effects. Melatonin reduces the free radical generation and metal detoxification .This study was planned to determine the effects of melatonin on aluminium induced toxicity in the chromosomes of bone marrow cell . Material and Methods ,Forty female albino rats were used in the present work for the chromosomal analysis. Four groups of adult female albino rats were used in the following way: Group -I, control group; Group-II,50 mg /kg b.wt aluminium orally; Group-III, 50μg / kg b.wt melatonin orally and Group- IV, 50 mg /kg b.wt aluminium orally (am) +50 μg / kg b.wt melatonin orally(pm). Doses were given 30 days. All animals were sacrificed and the bone marrow of femur bones was taken for subsequent cytogenetic studies. The results, Aluminium treatment induced a significant increase in the structural as well as numerical chromosomal aberrations . The frequency of chromosomal aberrations showed significant decrease when rats treated with melatonin and aluminium .In conclusion, the results indicated that melatonin showed a significant improvement of genetic damages induced by aluminium. | ||
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