K.Areida, S., S.ELhefnawy, A., A. mohammed, A., M.mohammed, K. (2020). Malondialdehyde, Catalase and Urinary Nerve Growth Factor As Noninvasive Diagnostic Tools For Overactive Bladder. test, 49(3), 72-77. doi: 10.21608/joese.2020.177133
Sayed K.Areida; Ahmed S.ELhefnawy; Amira A. mohammed; Kholoud M.mohammed. "Malondialdehyde, Catalase and Urinary Nerve Growth Factor As Noninvasive Diagnostic Tools For Overactive Bladder". test, 49, 3, 2020, 72-77. doi: 10.21608/joese.2020.177133
K.Areida, S., S.ELhefnawy, A., A. mohammed, A., M.mohammed, K. (2020). 'Malondialdehyde, Catalase and Urinary Nerve Growth Factor As Noninvasive Diagnostic Tools For Overactive Bladder', test, 49(3), pp. 72-77. doi: 10.21608/joese.2020.177133
K.Areida, S., S.ELhefnawy, A., A. mohammed, A., M.mohammed, K. Malondialdehyde, Catalase and Urinary Nerve Growth Factor As Noninvasive Diagnostic Tools For Overactive Bladder. test, 2020; 49(3): 72-77. doi: 10.21608/joese.2020.177133

Malondialdehyde, Catalase and Urinary Nerve Growth Factor As Noninvasive Diagnostic Tools For Overactive Bladder

Journal of Environmental Sciences. Mansoura University
Article 3, Volume 49, Issue 3, September 2020, Pages 72-77    PDF (396.1 K)
Document Type: Original Article
DOI: 10.21608/joese.2020.177133
Authors
Sayed K.Areida1; Ahmed S.ELhefnawy2; Amira A. mohammed3; Kholoud M.mohammed4
1Professor Assistant of molecular biology, faculity of science, Mansoura University
2Professor Assistant of urology, urology and nephrology Center, Mansoura University
3Fellow of cell biology, genetics and histology, urology and nephrology center, Mansoura University
4Department of cell biology, genetics and histology faculty of science, Mansoura University
Abstract
Chronic renal failure (CRF) is associated with male gonadal dysfunction that may lead to impotence, reduced libido, reduced size of testes and impaired spermatogenesis. The present study assesses the protective impact of Raphanus sativus seed extract (RSE) on testicular dysfunction and infertility associated with CRF induced by adenine in male rats. Twenty adult male albino rats were divided into four groups (5 each) and received their treatment for 4 weeks: group I, control; group II, (RSE): (0.52 ml/kg) orally via stomach tube, group III, (AD): (0.75 % W/W in diet), group IV, (RSE+ AD): received RSE and AD the same dose and route as groups II and III daily. The results showed a significant decline in the body weight gain, testicles and epididymides weights, testosterone level, semen quality ( sperm count, motility, and viability), reduced glutathione (GSH) level, superoxide dismutase (SOD) and catalase (CAT) activities, and increase in kidney weight, serum creatinine (SCr), BUN, uric acid, FSH & LH levels, sperm abnormality, malondialdehyde (MDA) & nitric oxide (NO) in AD treated rats, and histopathological alteration in kidney and testes tissue. But, RSE and AD co-administration partially successfully blocked these parameters and prevent histological structures abnormalities that nearly remain within normal levels in comparison with AD group < strong>.
Keywords
overactive bladder; catalase. Malondialdehyde; urinary nerve growth factor; marker; nitic coxide
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