Edrees, G., EL-Said, F., Salem., E. (2007). Protective Effect of Natural Honey, Urtica diocia and Their Mixture against Oxidative Stress Caused by Chronic Ethanol Consumption.. test, 27(1), 223-233. doi: 10.21608/ejhm.2007.17724
G.M.F Edrees; F.G. EL-Said; E.T. Salem.. "Protective Effect of Natural Honey, Urtica diocia and Their Mixture against Oxidative Stress Caused by Chronic Ethanol Consumption.". test, 27, 1, 2007, 223-233. doi: 10.21608/ejhm.2007.17724
Edrees, G., EL-Said, F., Salem., E. (2007). 'Protective Effect of Natural Honey, Urtica diocia and Their Mixture against Oxidative Stress Caused by Chronic Ethanol Consumption.', test, 27(1), pp. 223-233. doi: 10.21608/ejhm.2007.17724
Edrees, G., EL-Said, F., Salem., E. Protective Effect of Natural Honey, Urtica diocia and Their Mixture against Oxidative Stress Caused by Chronic Ethanol Consumption.. test, 2007; 27(1): 223-233. doi: 10.21608/ejhm.2007.17724

Protective Effect of Natural Honey, Urtica diocia and Their Mixture against Oxidative Stress Caused by Chronic Ethanol Consumption.

The Egyptian Journal of Hospital Medicine
Article 9, Volume 27, Issue 1, April 2007, Pages 223-233    PDF (336.12 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2007.17724
Authors
G.M.F Edrees1; F.G. EL-Said1; E.T. Salem.2
1Zoology Department, Faculty of Science, Mansoura University
2Zoology Department, Faculty of Science, Mansoura University.
Abstract
Background: There is increasing implicating oxidative stress in the pathogenesis of chronic pancreatitis. The aim of this study is to investigate affect alcohol addiction and role of some protecting agent.
Material and methods: Forty eight rats (Rattus norvigicus) were divided into 8 groups. Honey (2.5 g /kg b.w), Urtica dioica (250 mg/kg) and Alcohol orally administered at dose (20% exceeds by 2.5% weekly).
Results: Ethanol feeding results in increasing serum glucose, total lipids, cholesterol, Low Density Lipoprotein (LDL), triglycerides, urea, liver Glucose-6-Phosphatase (G6Pase), pancreas and liver Malondialdehyde (MDA), Protein Carbonyl (PC). While a decrease were noted in serum insulin, High Density Lipoprotein (HDL), total Protein, Na, K, Ca, Mg, Cu, liver glycogen, pancreas and liver Glucose-6-Phosphate Dehydrogenase (G6PD), Glutathione- S-Transferase (GST), Reduced Glutathione (GSH), Catalase (CAT), Superoxide Dismutase (SOD).
Conclusion: Administration of honey, urtica or both with alcohol prevent to great extent the lesions caused by only chronic alcohol administration. Consequently, honey and urtica administration are useful to minimize the hazardous effects resulting from ethanol abuse.
Keywords
Alcohol- Antioxidant- Honey; Oxidative Stress
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