El-Menyawy, H., Metwally, K., Aly, I., Abo Elqasem, A., Youssef, A. (2021). The Therapeutic role of Thymoquinone Bioactive Compound as Target Natural Product from Nigella sativa Loaded with Chitosan Nanoparticles on Schistosomiasis. test, 84(1), 1818-1826. doi: 10.21608/ejhm.2021.177604
Hend M. El-Menyawy; Karima M. Metwally; Ibrahim R. Aly; Asmaa A. Abo Elqasem; Alaa A. Youssef. "The Therapeutic role of Thymoquinone Bioactive Compound as Target Natural Product from Nigella sativa Loaded with Chitosan Nanoparticles on Schistosomiasis". test, 84, 1, 2021, 1818-1826. doi: 10.21608/ejhm.2021.177604
El-Menyawy, H., Metwally, K., Aly, I., Abo Elqasem, A., Youssef, A. (2021). 'The Therapeutic role of Thymoquinone Bioactive Compound as Target Natural Product from Nigella sativa Loaded with Chitosan Nanoparticles on Schistosomiasis', test, 84(1), pp. 1818-1826. doi: 10.21608/ejhm.2021.177604
El-Menyawy, H., Metwally, K., Aly, I., Abo Elqasem, A., Youssef, A. The Therapeutic role of Thymoquinone Bioactive Compound as Target Natural Product from Nigella sativa Loaded with Chitosan Nanoparticles on Schistosomiasis. test, 2021; 84(1): 1818-1826. doi: 10.21608/ejhm.2021.177604

The Therapeutic role of Thymoquinone Bioactive Compound as Target Natural Product from Nigella sativa Loaded with Chitosan Nanoparticles on Schistosomiasis

The Egyptian Journal of Hospital Medicine
Article 30, Volume 84, Issue 1, July 2021, Pages 1818-1826    PDF (583.69 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2021.177604
Authors
Hend M. El-Menyawy; Karima M. Metwally; Ibrahim R. Aly; Asmaa A. Abo Elqasem; Alaa A. Youssef
Abstract
Background: Schistosoma mansoni is a trematode helminth responsible for liver fibrosis or cirrhosis.
Aim of the work: In the present work natural products Thymoquinone loaded with chitosan nanoparticle (TQ/ChNP)) (TQ/ChNP) were used to determine their therapeutic effect on S. mansoni infection.  
Materials and methods: A total of 40 healthy Swiss albino mice, 20-25 g in weight, procured from Theodor Bilharz Research Institute (TBRI) Imbaba, Egypt's Schistosome Biological Supply Center (SBSC).    
Results: The infected mice treated with TQ/ChNP showed a significant decrease in the total worm burden. Treatment with TQ/ChNP had a highly significant effect on mature worm burden, TQ/ChNP in prophylactic and therapeutic doses significantly increased the mean number of dead ova in comparison to control. TQ/ChNP had a high decrease effect on ova count in intestinal tissue and a moderate reduction on ova count in hepatic tissue. Prophylactic dose gave a high reduction effect on ova count in intestinal tissue. As regards the size of hepatic granuloma, TQ/ChNP had the highest significant reduction on mean granuloma diameter with noticeable improvement of hepatic pathology. TQ/ChNP treated group showed observable improvement of liver pathology with mild degeneration and slight-sized fibrocellular. Conclusion: Based on the outcome of this study, TQ/ChNP proved to have potential bioactivity against S. mansoni adult stages and its potentiality in improving hepatic pathology. Efficacy of TQ/ChNP to postpone progression in chronic liver diseases must be considered as preventive medicine in patients with hepatic disorders.
 
 
Keywords
S. mansoni infection; Nigella sativa; (TQ/ChNP); Chitosan; Oogram; Granuloma formation
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