Elazazy, M., Shalaby, A., Elbalkiny, M., Khalil, H. (2004). SPECTROPHOTOMETRIC DETERMINATION OF DAPSONE AND TRANEXAMIC ACID USING HANTZSCH REACTION AND ITS APPLICATION IN PHARMACEUTICAL FORMULATIONS. test, 13(1), 6-11. doi: 10.21608/zjps.2004.177900
Marwa Elazazy; Abdalla Shalaby; Mohamed Elbalkiny; Hawa Khalil. "SPECTROPHOTOMETRIC DETERMINATION OF DAPSONE AND TRANEXAMIC ACID USING HANTZSCH REACTION AND ITS APPLICATION IN PHARMACEUTICAL FORMULATIONS". test, 13, 1, 2004, 6-11. doi: 10.21608/zjps.2004.177900
Elazazy, M., Shalaby, A., Elbalkiny, M., Khalil, H. (2004). 'SPECTROPHOTOMETRIC DETERMINATION OF DAPSONE AND TRANEXAMIC ACID USING HANTZSCH REACTION AND ITS APPLICATION IN PHARMACEUTICAL FORMULATIONS', test, 13(1), pp. 6-11. doi: 10.21608/zjps.2004.177900
Elazazy, M., Shalaby, A., Elbalkiny, M., Khalil, H. SPECTROPHOTOMETRIC DETERMINATION OF DAPSONE AND TRANEXAMIC ACID USING HANTZSCH REACTION AND ITS APPLICATION IN PHARMACEUTICAL FORMULATIONS. test, 2004; 13(1): 6-11. doi: 10.21608/zjps.2004.177900

SPECTROPHOTOMETRIC DETERMINATION OF DAPSONE AND TRANEXAMIC ACID USING HANTZSCH REACTION AND ITS APPLICATION IN PHARMACEUTICAL FORMULATIONS

Zagazig Journal of Pharmaceutical Sciences
Article 2, Volume 13, Issue 1, June 2004, Pages 6-11    PDF (2.3 M)
Document Type: Original Article
DOI: 10.21608/zjps.2004.177900
Authors
Marwa Elazazy* 1; Abdalla Shalaby2; Mohamed Elbalkiny2; Hawa Khalil2
1Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig. Egypt
2Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
Abstract
A simple, rapid, sensitive and specific spectrophotometric method has been developed for the determination of two primary amines of pharmaceutical interest; dapsone and tranexamic acid. The method is based on condensation of the cited drugs with acetylacetone - formaldehyde mixture in acetic acid - sodium acetate buffer media by aid of heating at (97± 0.5°C) for a fixed time to yield a yellow colored condensation product ''dihydrolutidine derivative'' and possess a characteristic absorption maxima at 330 -345 nm. The variables affecting color development and the stability of the reaction product have been investigated and the conditions optimized. Beer's law is obeyed in the concentration range of 1 - 11 µg ml-1 with molar absorpitivities ranging from 1.475x104-2.015x104 L.mol-1cm-1 and Sandell sensitivities of 8.11x10-3-9.38x10-3 µg cm-2. The proposed spectrophotometric procedure was applied successfully for the determination of the cited drugs in some of their pharmaceutical formulations.
Statistics
Article View: 117
PDF Download: 73