EL – Nakeeb, S., A.Lattif, M., .Ragheb, A., Albow, B. (2006). Plasma Adiponectin and Resistin Levels in Type 2 Diabetic Obese Female Patients With and Without Hypertension and Retinopathy. test, 24(1), 515-523. doi: 10.21608/ejhm.2006.17914
Seham M. S. EL – Nakeeb; Manal A.Lattif; Ahmed M .Ragheb; Baker M.A. Albow. "Plasma Adiponectin and Resistin Levels in Type 2 Diabetic Obese Female Patients With and Without Hypertension and Retinopathy". test, 24, 1, 2006, 515-523. doi: 10.21608/ejhm.2006.17914
EL – Nakeeb, S., A.Lattif, M., .Ragheb, A., Albow, B. (2006). 'Plasma Adiponectin and Resistin Levels in Type 2 Diabetic Obese Female Patients With and Without Hypertension and Retinopathy', test, 24(1), pp. 515-523. doi: 10.21608/ejhm.2006.17914
EL – Nakeeb, S., A.Lattif, M., .Ragheb, A., Albow, B. Plasma Adiponectin and Resistin Levels in Type 2 Diabetic Obese Female Patients With and Without Hypertension and Retinopathy. test, 2006; 24(1): 515-523. doi: 10.21608/ejhm.2006.17914

Plasma Adiponectin and Resistin Levels in Type 2 Diabetic Obese Female Patients With and Without Hypertension and Retinopathy

The Egyptian Journal of Hospital Medicine
Article 9, Volume 24, Issue 1, July 2006, Pages 515-523    PDF (333.61 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2006.17914
Authors
Seham M. S. EL – Nakeeb1; Manal A.Lattif2; Ahmed M .Ragheb3; Baker M.A. Albow4
1Biochemistry Dept Faculty of Medicine for Girls AL-Azhar University Clinical Pathology Dept
2Internal Medicine Dept Faculty of Medicine for Girls AL-Azhar University Clinical Pathology Dept
3Faculty of Medicine AL-Azhar University, Faculty of Medical Technology
4Mesalata- El- Margeb University
Abstract
Background: In the past, adipose tissue was largely regarded as a depot for fuel storage in the form of triglyceride. However, adipose tissue is an active endocrine organ that secretes a variety of metabolically important substances including adipokines. The adipocyte is now known to secrete a variety of proteins such as tumour necrosis factor (TNF)- , adipsin, plasminogen activator inhibitor-1, leptin, resistin, and adiponectin. Adipose tissue regulates insulin sensitivity via the circulating adipocytokines, resistin and adiponectin. These factors affect insulin sensitivity and may represent a link between obesity, insulin resistance and type 2 diabetes (DM). The objective of this study was to compare the levels of resistin and adiponectin in type 2 diabetic obese female patients with and without hypertension and retinopathy.
Subjects and Methods: In this study the plasma adiponectin and resistin concentrations were investigated, in 20 control obese non-diabetic females and 40 obese female patients with type 2 diabetes mellitus. The diabetic females were divided into 2 groups. GI included 20 controlled uncomplicated diabetics & GII included 20 diabetic patients with hypertension and retinopathy.
Results: The plasma concentration of adiponectin was significantly lower (P< 0.01) in diabetic females in GΙ & GΠ than non-diabetic control females. In diabetic patients with hypertension and retinopathy ( GII) there was a significant decrease in plasma adiponectin levels (P< 0.01) as compared to their levels in diabetic females in GΙ and control females. Our results also show that there were non-significant changes in plasma resistin in diabetic patients in both groups GΙ & GII as compared to their levels in control group.
Conclusion: These results suggest that adiponectin may play a key role in pathophysiology of type 2 diabetes mellitus and its microangiopathy and macrovascular complications.




Key words: diabetes mellitus . obesity Introduction
 
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