Is there any possible role for telocytes in the pathogenesis of musculoskeletal diseases? | ||
| Journal of Medical Histology | ||
| Article 10, Volume 4, Issue 1, June 2020, Pages 126-132 PDF (819.9 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jmh.2021.54933.1088 | ||
| Authors | ||
| Ali El Deeb1; Ahmed Abd El Hafez2; Amal Abd El Hafez* 3 | ||
| 1Departments of Rheumatology Physical Medicine and Rehabilitation, Faculty of Medicine, Tanta University, Egypt | ||
| 2Anesthesia And Pain Management, Faculty of Medicine, Tanta University, Egypt | ||
| 3Departments of Histology and Cell Biology, Faculty of Medicine, Tanta University, Egypt | ||
| Abstract | ||
| Background: Telocytes (Tc) are newly discovered histological cells that are scattered within most of the tissues and organs including the musculoskeletal system. They are a peculiar type of interstitial cells with very long prolongations termed telopodes (Tp). They have also been isolated and cultured from tissues in vitro. Some recent researches have been done handling the possible physiological function of these cells and the pathophysiological role in some musculoskeletal diseases. In any case, future functional studies of telocytes in vivo will help to understand the mechanism by which telocytes contribute to tissue homeostasis in health and disease. Aim: We are in need to highlight on these cells to widen the scope of research about the potential hidden roles of telocytes in the pathogenesis of some rheumatic diseases. Conclusion: Hence this review focuses on the latest progresses regarding Tc in the pathogenesis and/or repair and regeneration of different tissues like skeletal muscle, synovium and peripheral nerves. | ||
| Keywords | ||
| Musculoskeletal; system; telocyts | ||
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