Jasim, R., Mohammad, S., Allwsh, T. (2021). The Relation Between Fibroblast Growth Factor 21 and Insulin Resistance in hyperlipidemia Patients. test, 64(12), 7091-7097. doi: 10.21608/ejchem.2021.80062.3947
Rana F. Jasim; Safaa S. Mohammad; Thikra A. Allwsh. "The Relation Between Fibroblast Growth Factor 21 and Insulin Resistance in hyperlipidemia Patients". test, 64, 12, 2021, 7091-7097. doi: 10.21608/ejchem.2021.80062.3947
Jasim, R., Mohammad, S., Allwsh, T. (2021). 'The Relation Between Fibroblast Growth Factor 21 and Insulin Resistance in hyperlipidemia Patients', test, 64(12), pp. 7091-7097. doi: 10.21608/ejchem.2021.80062.3947
Jasim, R., Mohammad, S., Allwsh, T. The Relation Between Fibroblast Growth Factor 21 and Insulin Resistance in hyperlipidemia Patients. test, 2021; 64(12): 7091-7097. doi: 10.21608/ejchem.2021.80062.3947

The Relation Between Fibroblast Growth Factor 21 and Insulin Resistance in hyperlipidemia Patients

Egyptian Journal of Chemistry
Article 22, Volume 64, Issue 12, December 2021, Pages 7091-7097    PDF (307.49 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.80062.3947
Authors
Rana F. Jasim1; Safaa S. Mohammad2; Thikra A. Allwsh2
1Department of chemistry, Collage of Education for Girls, University of Mosul, Mosul, Iraq
2Department of chemistry, Collage of Science, University of Mosul, Mosul, Iraq
Abstract
This research included study the relation between FGF21 and insulin resistance in hyperlipidaemia. The results demonstrated that the normal mean of FGF21 in serum control group was (69.4±2.9 pg/ml) and there was a significant increasing in FGF21 concentration in patients (108.05±4.03 pg/ml ) compared with control group, also the results showed a significant increase in the concentration of fasting glucose, insulin, homeostasis model for insulin resistance (HOMA-IR), Total cholesterol, Triglycerides, low density lipoprotein for cholesterol (LDL-C) and very low density lipoprotein for cholesterol (VLDL-C) and Malondialdehyde (MDA), while a significantly decrease had been shown in concentration of high density lipoprotein for cholesterol (HDL-C), adiponectin and Arylestase activity in hyperlipidemia patients compared with control group. Correlation coefficients of FGF21 hormone with these clinical parameters showed a positivly significant correlation with Glucose, insulin, HOMA-IR, Total cholesterol, Triglycerides, LDL-C, VLDL-C and MDA concentration, while FGF21 elucidated a significant negative correlation with HDL-C, arylesterase activity and adiponectin concentration. The conclusion of this study was that FGF21 concentration corelated significantly in hyperlipidemia with insulin resistance, and FGF21 high concentration can be represented as a biomarker in hyperlipidemia.
Keywords
Adiponectin; FGF21; hyperlipidemia; Insulin resistance
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