Albuminuria Independently Determines Intact Parathyroid Hormone in Diabetic Nephropathy with Micro-albuminuria | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 66, Volume 84, Issue 1, July 2021, Pages 2052-2056 PDF (389.47 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2021.180351 | ||
| Authors | ||
| mohammed ali gameil; Rehab Elsayed Marzouk; Ahmed Hassan Elsebaie; Ahmed Ahmed Ahmed Eldeeb | ||
| Internal medicine department, Faculty of medicine, Mansoura University, Mansoura, Dakahlia, Egypt. | ||
| Abstract | ||
| Background: Diabetes mellitus (DM) is a well-recognised cause of end-stage renal disease (ESRD) through diabetic nephropathy (DN). Elevated intact parathyroid hormone (intact PTH) in DN represents a serious metabolic threat. Objective: We aimedto detect determinants of intact PTH changes during micro-albuminuria stage of DN. Patients and Methods: An observational study included 294 patients with type 2 diabetes mellitus (T2D) divided into 2 groups. Case group; 220 patients of DN with micro-albuminuria versus control group; 74 patients without albuminuria. Participants were subjected to history taking, clinical examination and laboratory assessment of glycosylated haemoglobin (HBA1c), serum creatinine, blood urea nitrogen (BUN), urine albumin creatinine ratio (urine ACR), estimated glomerular filtration rate (eGFR), 25(OH) vitamin D, intact PTH, serum ionized calcium, phosphorus and magnesium. Results: Among 220 patients of mean age 48.7 years and 57.7% male, albuminuria was significantly higher (P<0.001). We found non-significant difference between the study groups in estimated glomerular filtration rate (eGFR) and serum creatinine (P=0.375 and 0.294) respectively. Meanwhile, intact PTH was significantly elevated (P<0.001) in case group. Intact PTH was positively correlated with urine ACR, HBA1c, BUN, and serum creatinine and inversely correlated with eGFR. However, urine ACR was the only independent determinant of intact PTH in diabetic patients with micro-albuminuria (OR: 1.177; 95% CI: 1.074-1.290, P= 0.001). Conclusion: Interestingly, urine albumin creatinine ratio was the only independent determinant of intact PTH in diabetic patients with micro-albuminuria. | ||
| Keywords | ||
| Diabetic nephropathy; Intact PTH; Micro-albuminuria | ||
|
Statistics Article View: 240 PDF Download: 424 |
||
