Biochemical Effects Of Ribavirin (Antiviral) And Ddb (Hepato Protective) Drugs In Albino Rats | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 9, Volume 20, Issue 1, July 2005, Pages 83-93 PDF (407.54 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2005.18096 | ||
| Authors | ||
| Soliman S. Ibrahim; Amr Shalaby; Mahmoud Rabeh | ||
| Zoology Department, Faculty of Science, Zagazig University | ||
| Abstract | ||
| The present investigation has been designed to through spot light on the efficiency of these two drugs in treatment of hepatitis patients. Cortisol, antigliadin (1gG) , total protein (TP) albumin (ALB) , Iron (Fe) , alanine aminotransferase (ALT) , aspartic aminotransferase (AST) and alkaline phosphatase (ALP) were determined in serum of normal mature male and female albino rats that injected intraperitoneally day after day with 1mg/kg body weight of each drug separately for 3 months. The cortisol level and ALP showed significant increase in each of ribavirin or DDB treated animals, while the IgG concentration in ribavirin treated animals increased significantly, but it is did not vary greatly from that of the control in DDB treated animals. On the other hand both ribavirin and DDB treated male and female rats showed significant decrease in the ALT in serum while serum AST elicited non significant decrease in each of ribavirin and DDB treated male and female. With respect to serum TP and ALB levels the result showed significant decrease in ribavirin and non significant decrease in DDB treated male and female rats. Furthermore, the serum Fe level in ribavirin treated male and female rats increased significantly but it is did not vary greatly from that of the control in DDB treated animal. | ||
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