Toxic Effects Of Some Antispastic Drugs on the EEG: Some Biochemical And Immunological Studies on Rats. | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 17, Volume 20, Issue 1, July 2005, Pages 196-215 PDF (1.05 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2005.18104 | ||
| Authors | ||
| Fathy El-Komey; Inass EL-Gaafarawi; Hanan Moustafa | ||
| The National Center for Social and Criminological Research, Zamalek, P.O., P.C.11561, Cairo, Egypt. | ||
| Abstract | ||
| The toxicity of tizanidine and baclofen was studied on male rats. The oral clinical dose of tizanidine and baclofen( 0.216 and o.54 mg/ 100g body weight / day, respectively)was given for one, two, three and four weeks. Chronic administration of the two drugs causes damage to the lung and a significant reduction in serum and lung levels of GSH , Vit E , Vit C and SOD activity . Four weeks treatment induced significant elevation of GPX activity and MDA levels. The two drugs, also, caused inhibitory activity on proliferation of splenocyte triggered by Con A, LPS and IL-2 production cell activities. They also produced several abnormal patterns in the EEG including increased epileptiform discharges and synchronous rhythmic activity . Diffuse slowing , with increased beta and delta activity and decreased alpha activity , with superimposed beta activity were recorded. than baclofen . | ||
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