Histological Study Of The Effect Of Zinc Sulphate On The Toxicity Of Aluminium Sulphate In Liver And Kidney Of Male Albino Rats | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 17, Volume 19, Issue 1, April 2005, Pages 189-197 PDF (433.96 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2005.18121 | ||
| Author | ||
| Azza M. Gawish | ||
| Department of zoology, Faculty of Science, Cairo University, Cairo, Egypt | ||
| Abstract | ||
| Aluminium (Al) is one of the most abundant and important elements in the environment. In recent years, the production of this metal and its toxicity increased with its discharge into the environment. This study was designed to evaluate the effect of Al intake toxicity in liver and kidney tissues of albino rats and the role of zinc as a protective agent against Al toxicity. Fourty five male albino rats were divided into equal three groups. The first group of animals was considered as control. The animals in the second group were given (50mg/kg/day) of Al sulphate orally using gastric tube for 45 day. Third group were given Al sulphate (50mg/kg/day) followed by zinc sulphate (50mg/kg/day) orally as well as samples of liver and kidney tissues were obtained after 15, 30, 45 days of last doses respectively. Paraffin sections (5μm) were prepared for histological study stained with Haematoxylin & Eosin. The obtained histological results of the histological study of the second group showed that there were congested blood sinusoids and swelling of some hepatocytes within cytoplasm in which there were vacuoles, fragmented nuclei with some cellular infiltration. Kidney tissue showed shrinkage of some glomeruli and distortion of the tubular epithelial cells. Results in the third group, where zinc sulphate was added, showed amelioration and improvement in both liver and kidney tissues. | ||
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