PRELMINARY EVALUATION OF QUERCETIN EFFECT ON DICLOFENAC SODIUM ASSOCIATED GASTRIC ULCER IN RATS. | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Article 5, Volume 10, Issue 1, June 2001, Pages 25-28 PDF (2.07 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjps.2001.181591 | ||
| Authors | ||
| Mohamed Abdel Mohsen* 1; Gamal Hasan2 | ||
| 1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt. | ||
| 2Department of Pharmacology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||
| Abstract | ||
| The effect of quercetin (QRT) in preventing or reducing the diclofenac sodium-induced gastric ulcers was evaluated in rats following over night fasting by using a scanning electron microscopy. The scanning micrographs of stomach specimens showed a marked reduction in the gastric ulceration only when the quercetin is given before the administration of diclofenac sodium. The physicochemical characteristics of diclofenac sodium and quercetin combination were studied using differential scanning calorimetry, IR spectroscopy and X-ray diffractometery. The results revealed that a chemical incompatibility of diclofenac sodium and quercetin undoubtedly has been occurred when they were mixed in one combination. According to aforementioned results, we advise orally taking quercetin only before administration of diclofenac sodium as a prophylactic treatment to protect against its expected gastric disturbances. | ||
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