El-Sabbagh, O., Abd-El Alim, A. (2000). SYNTHESIS OF NEW NONCLASSICAL DIBENZODIAZEPINE DERIVATIVES AS POTENTIAL ANTIPSYCHOTIC AGENTS. test, 9(1), 9-16. doi: 10.21608/zjps.2000.181618
Osama El-Sabbagh; Abd-El Alim Abd-El Alim. "SYNTHESIS OF NEW NONCLASSICAL DIBENZODIAZEPINE DERIVATIVES AS POTENTIAL ANTIPSYCHOTIC AGENTS". test, 9, 1, 2000, 9-16. doi: 10.21608/zjps.2000.181618
El-Sabbagh, O., Abd-El Alim, A. (2000). 'SYNTHESIS OF NEW NONCLASSICAL DIBENZODIAZEPINE DERIVATIVES AS POTENTIAL ANTIPSYCHOTIC AGENTS', test, 9(1), pp. 9-16. doi: 10.21608/zjps.2000.181618
El-Sabbagh, O., Abd-El Alim, A. SYNTHESIS OF NEW NONCLASSICAL DIBENZODIAZEPINE DERIVATIVES AS POTENTIAL ANTIPSYCHOTIC AGENTS. test, 2000; 9(1): 9-16. doi: 10.21608/zjps.2000.181618

SYNTHESIS OF NEW NONCLASSICAL DIBENZODIAZEPINE DERIVATIVES AS POTENTIAL ANTIPSYCHOTIC AGENTS

Zagazig Journal of Pharmaceutical Sciences
Article 2, Volume 9, Issue 1, June 2000, Pages 9-16    PDF (3.25 M)
Document Type: Original Article
DOI: 10.21608/zjps.2000.181618
Authors
Osama El-Sabbagh* 1; Abd-El Alim Abd-El Alim2
1Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
2Depart. of Pharmacology, Faculty of Vet. Medicine , Zagazig University, Zagazig, Egypt.
Abstract
Two series of 8-chloro-2, 3, 4, 5,10,11-hexahydro-11-substituted-1H-dibenzob,e 1,4 diazepine-1-ones and their3,3- dimethyl analogs were prepared via internal Mannich reaction of 3-[(2- amino-4- chlorophenyl) amino] -2-cyclohexen-1-one and its 5,5-dimethyl analog, respectively, with different aldehydes at room temperature. The synthesized compounds were evaluated for their clozapine-like properties. The structures of the novel compounds were confirmed using elemental analyses and different spectroscopic methods. Pharmacological evaluation of some of the synthesized dibenzodiazepine derivatives revealed that compounds 4 and 17 (having 4-bromophenyl moiety) exhibited a high antipsychotic and sedative properties.
Statistics
Article View: 97
PDF Download: 70