Khattab, R., swelm, S., Khalil, A., Elsayed Abdelhamid, A., Soliman, A., El-Sayed, A. (2021). Novel Sono-synthesized Triazole Derivatives Conjugated with Selenium Nanoparticles for cancer treatment. test, 64(8), 4675-4688. doi: 10.21608/ejchem.2021.81154.4018
Reham Khattab; samira ABO Sreaa swelm; Ahmed M. Khalil; Ahmed Elsayed Abdelhamid; Abdelmohsen M. Soliman; Ahmed El-Sayed. "Novel Sono-synthesized Triazole Derivatives Conjugated with Selenium Nanoparticles for cancer treatment". test, 64, 8, 2021, 4675-4688. doi: 10.21608/ejchem.2021.81154.4018
Khattab, R., swelm, S., Khalil, A., Elsayed Abdelhamid, A., Soliman, A., El-Sayed, A. (2021). 'Novel Sono-synthesized Triazole Derivatives Conjugated with Selenium Nanoparticles for cancer treatment', test, 64(8), pp. 4675-4688. doi: 10.21608/ejchem.2021.81154.4018
Khattab, R., swelm, S., Khalil, A., Elsayed Abdelhamid, A., Soliman, A., El-Sayed, A. Novel Sono-synthesized Triazole Derivatives Conjugated with Selenium Nanoparticles for cancer treatment. test, 2021; 64(8): 4675-4688. doi: 10.21608/ejchem.2021.81154.4018

Novel Sono-synthesized Triazole Derivatives Conjugated with Selenium Nanoparticles for cancer treatment

Egyptian Journal of Chemistry
Article 65, Volume 64, Issue 8, August 2021, Pages 4675-4688    PDF (665.32 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.81154.4018
Authors
Reham Khattab1; samira ABO Sreaa swelm2; Ahmed M. Khalil3; Ahmed Elsayed Abdelhamid4; Abdelmohsen M. Soliman5; Ahmed El-Sayed* 6
1NRC_Photochemistry
2photochemistry, NRC, Egypt, Cairo
3El Buhouth St., Dokki 12622
4national research centre
5Therapeutic Chemistry Dept. National Research Centre, Elbehouth St. Dokki, Giza, Egypt.
6Photochemistry Department, Industrial Research Division, national research Centre, Dokki, Cairo, Egypt
Abstract
Green chemistry is among the important applied aspects to synthesize novel bioactive compounds. We aim to provide triazole derivatives using eco-friendly methods such as sonication technology. This procedure was performed by using natural catalysts such as natural citrus squeezes. Ultrasonic irradiation was employed in the presence of natural juices such as lemon or/and orange juice to synthesize triazole derivatives. The synthesized compounds were investigated using FTIR, 1H-NMR, 13C-NMR, mass spectroscopy and elemental analysis. The cytotoxicity and in vitro anticancer evaluation of the synthesized triazole derivatives and the derivatives selenium nanoparticles have been assessed towards human liver cancer cell line (HEGP2) in addition to BALB/3T3 (murine fibroblast) normal cell line. Some compounds showed an active selectivity towards the human liver cancer cell line (HEGP2). However, they have no activity for the BALB/3T3 (murine fibroblast) normal cell line. Meanwhile, after evaluating the cytotoxicity of the synthesized compounds and in vitro anticancer activities, compounds 12a, 12b, 13a, 13b were selected to contribute in synthesizing in-situ selenium nanoparticles (SeNPs). The results showed a significant in vitro antiproliferative activity of the synthesized compounds.
Keywords
Green Chemistry; Triazoles; Selenium nanoparticles; Ultrasonic Technology; liver cancer cell line (HEPG2); Normal cell line (BALB/3T3)
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