Is Deficiency of 25-Hydroxy Vitamin D A Risk Factor for Autism? A Preliminary Study | ||
| Egyptian Journal of Ear, Nose, Throat and Allied Sciences | ||
| Article 34, Volume 22, Issue 22, January 2021, Pages 1-9 PDF (436.84 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejentas.2021.44200.1264 | ||
| Authors | ||
| Megahed Mohamed Hassan* 1; Ahmed Aboud Emam1; Ashraf Radwan2; Amany Abdelhameed3; Sameh Salah Eldin4; Montasser Mohamed2 | ||
| 1Phoniatrics Unit, Otolaryngology, Faculty of Medicine, Sohag University, Sohag, Egypt | ||
| 2Pediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt | ||
| 3Physiology, Faculty of Medicine, Sohag University, Sohag, Egypt | ||
| 4Medical Biochemistry, Faculty of Medicine, Assuit AlAzhar University, Assuit, Egypt | ||
| Abstract | ||
| Objective: To investigate the status of 25-hydroxy-vitamin-D [25-(OH)-D] in autistic children and to correlate with their mothers vitamin statuses and autism severity. Methods: In this case-control study, serum 25(OH)-D was measured in autistic children and controls (n=36 each) and in mothers of autistics and control mothers (n=24 each). Comparison and correlation studies were performed. Results: Both autistic children and their mothers have lower 25-(OH)-D compared to their controls with significant differences (PConclusion: Deficiency of 25(OH)-D is common in autistic children and related to the severity of symptoms. Vitamin D deficiency in children might be maternal-dependent. Deficiency of 25(OH)-D in autistic children and their mothers could be the primary predisposing factor for autism. This may find a common link among the genetic, immunological, anatomical, biochemical and physiological factors putting the puzzles together. Early supplementation of vitamin D could improve autistic manifestations. | ||
| Keywords | ||
| 25(OH)-D; ASD' mothers; autism; common factor; predisposing factor | ||
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