Simple and Efficient Methods for the Synthesis of New Biologically Active Heterocycles | ||
| Journal of Scientific Research in Science | ||
| Article 37, Volume 33, part1, September 2016, Pages 463-488 PDF (440.09 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jsrs.2016.18344 | ||
| Authors | ||
| Rana A. Elzamly* 1; Howida T. Zaky1; nadia G. Kandile2 | ||
| 1Department of Chemistry, Faculty of Women, Ain Shams University, Heliopolis,11757 Cairo, Egypt | ||
| 2Chemistry Department Faculty of Women, Ain shams University,Heliopolis,Cairo,Egypt | ||
| Abstract | ||
| An efficient and simple synthesis of fused pyridazine derivatives has been developed. These fused pyridazines were used as key starting material for the preparation of new heterocyclic compounds. All the structures of the newly synthesized compounds were confirmed on the basis of FT-IR, 1H and 13CNMR, mass spectral techniques. Six of the new synthesized compounds (6f , 8c-f and 8i) were selected and tested against a panel human tumor cell line HCT-116 (colon cancer) using Imatinib as standard drug. The cytotoxicity data of the tested compounds virus Imatinib in means of IC50 values were (6f, 8c-f and 8i) recorded as in (Figure I). The obtained data showed that the compounds 1-(3-(2-methoxyphenyl)-7-methoxyphenylisoxazolo[4,5-d]pyridazin-4-yl)hydrazine (8i) and 1-(3-(2-methoxyphenyl)-1-phenyl-7-methoxyphenyl-1H-pyrazolo[4,3-d]pyridazin-4-yl)hydrazine (8f) have high reactivity towards cell line HCT-116 (colon cancer) more than the standard drug Imatinib. | ||
| Keywords | ||
| Heterocyclic compounds; Fused pyridazines; Tetrazolo; Sulfonamide; Colon cancer | ||
|
Statistics Article View: 208 PDF Download: 266 |
||
