Conventional and Microwave Synthesis of Some New Pyridine Derivatives and Evaluation Their Antimicrobial and Cytotoxic Activities | ||
| Egyptian Journal of Chemistry | ||
| Article 11, Volume 62, Issue 4, April 2019, Pages 707-726 PDF (1.43 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2018.5115.1452 | ||
| Authors | ||
| Kurls Anwer* 1; Galal Sayed2; Hamdy Hassanan2; Mohammed Azab2 | ||
| 1chemistry, faculty of science, ain shams, cairo, egypt | ||
| 2Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt | ||
| Abstract | ||
| The newly synthesized compounds based on 2-amino-6-(2,4-dimethoxyphenyl)-4-(4-methoxyphenyl)nicotinonitrile 1. The reactivity of pyridine derivative 1 was studied towards different reagents by its reaction with malononitrile, 2-(4-chlorobenzylidene)malononitrile, ethyl cyanoacetate, cyano acetic acid, m-nitro benzaldehyde, sodium azide, formamide, acetic anhydride and/or acetic anhydride/H2SO4 to give compounds 2-5,7, 10-13, respectively. The reaction of 5 with acetyl acetone gave the bipyridine derivative 6, while reaction of compound 7 with chloroacetyl chloride and phenacyl bromide gave the azetidinone derivatives 8 and 9. The formimidate 14 were obtained via reaction of compound 1 with triethylorthoformate, while reaction of 14 with phenylene diamine and/or acetamide gave the formimidamide and pyridopyrimidine derivatives 15 and 16 respectively. Compound 1 was also allowed to react with urea, thiourea, phthalic anhydride, succinic anhydride, benzoyl chloride, chloroacetonitrile, chloroacetyl chloride, p-toluenesulfonylchloride and ethyl bromoacetate to give compounds 17a,b - 24. Reaction of compound 1 with dichloro reagents in 1:1 ratio gave the bicyclic derivatives 25a–c, while its reaction with oxalyl chloride, dichloro and tetrachlorobenzoquinone derivatives, and/or dichloronaphthoquinone gave the imidazopyridine derivatives 26-29. Reaction of compound 29 with o-phenylenediamine in 1:2 ratio afforded the di-condenesed product 30 while, reaction of compound 1 with dichlororeagents in 1:2 ratio gave the polyalkyl derivatives 31a-b. The newly synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR and mass spectra. On the other hand the antimicrobial and anticancer activities of some of the newly synthesized compounds was studied and evaluated. | ||
| Keywords | ||
| Pyridine; one pot condensation; naphthyridine; Pyrimidine; Antimicrobial; Anticancer; Microwave irradiation | ||
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