Soliman, S., El-Adl, S., Metwally, K., Abou-Kull, M. (1999). UTILITY OF DICHLOROMALEIMIDE DERIVATIVE AS A CHROMOGENIC REAGENT FOR THE SPECTROPHOTOMETRIC DETERMINATION OF CERTAIN FLUOROQUINOLONES AND RELATED COMPOUNDS. test, 8(2), 13-17. doi: 10.21608/zjps.1999.183916
Suzan Soliman; Sobhy El-Adl; Kamel Metwally; Mansour Abou-Kull. "UTILITY OF DICHLOROMALEIMIDE DERIVATIVE AS A CHROMOGENIC REAGENT FOR THE SPECTROPHOTOMETRIC DETERMINATION OF CERTAIN FLUOROQUINOLONES AND RELATED COMPOUNDS". test, 8, 2, 1999, 13-17. doi: 10.21608/zjps.1999.183916
Soliman, S., El-Adl, S., Metwally, K., Abou-Kull, M. (1999). 'UTILITY OF DICHLOROMALEIMIDE DERIVATIVE AS A CHROMOGENIC REAGENT FOR THE SPECTROPHOTOMETRIC DETERMINATION OF CERTAIN FLUOROQUINOLONES AND RELATED COMPOUNDS', test, 8(2), pp. 13-17. doi: 10.21608/zjps.1999.183916
Soliman, S., El-Adl, S., Metwally, K., Abou-Kull, M. UTILITY OF DICHLOROMALEIMIDE DERIVATIVE AS A CHROMOGENIC REAGENT FOR THE SPECTROPHOTOMETRIC DETERMINATION OF CERTAIN FLUOROQUINOLONES AND RELATED COMPOUNDS. test, 1999; 8(2): 13-17. doi: 10.21608/zjps.1999.183916

UTILITY OF DICHLOROMALEIMIDE DERIVATIVE AS A CHROMOGENIC REAGENT FOR THE SPECTROPHOTOMETRIC DETERMINATION OF CERTAIN FLUOROQUINOLONES AND RELATED COMPOUNDS

Zagazig Journal of Pharmaceutical Sciences
Article 3, Volume 8, Issue 2, December 1999, Pages 13-17    PDF (2.51 M)
Document Type: Original Article
DOI: 10.21608/zjps.1999.183916
Authors
Suzan Soliman1; Sobhy El-Adl* 2; Kamel Metwally3; Mansour Abou-Kull4
1National Organization for Drug Control and Research, Giza, Egypt.
2Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt
3Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig. Egypt
4Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt
Abstract
A simple and sensitive spectrophotometric procedure is described for the quantitative determination of certain fluoroquinolones (ciprofloxacin, enoxacin, and norfloxacin) either in authentic samples or in their pharmaceutical formulations. The cited drugs are interacted with a synthetic reagent, N-2,6-dimethylphenyl-2,3-dichloromaleimide forming an intense colour which can be measured at Amax 514 nm. The optimum interaction conditions, molar ratio of the reactants, and calibration graphs have been studied. A comparative study with the official pharmacopoeial methods of assay of the cited drugs showed no significant difference between them. Furthermore, the proposed procedure was more sensitive and selective. Moreover, the reaction product was isolated and subjected to the structural study using IR and NMR spectroscopy.
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