IMMUNOTOXIC RESPONSE OF FEMALE BALB/C MICE TO DIAZIONE; CARBOFURAN AND CYPERMETHRINE INSECTICIDES | ||
| Assiut Veterinary Medical Journal | ||
| Article 23, Volume 32.2, Issue 64, January 1995, Pages 207-215 PDF (2.45 M) | ||
| Document Type: Research article | ||
| DOI: 10.21608/avmj.1995.184046 | ||
| Author | ||
| M. ABDEL-NASSER | ||
| Abstract | ||
| The immunotoxic effect of diazinon, carbofuran and cypermethrin was evaluated in female BALB/C mice. Mice were dosed by gavage with 0.01, 0.001 and 0.0001 of the oral LDso of each technical insecticide. The lymphocyte proliferation assays were used to measure the functional activity of thymus-dependent (T-cells) and bursal equivalent (B-cells) lymphocytes by concanavalin A (con A) or lipopolysacharide (LPS). Mitogenesis or cell proliferation was measured by tritiated thymidine (H) incorporation. Results reveal, no changes in body weight except with the high dose of cypermethrin. Reduction in spleen cellularity and weight of intoxicated mice were recorded. In addition the mixed lymphocyte reaction (MLR) of the spleenic cells was changed. Lymphocyte proliferative reponses to Concanavalin A (con A) and Lipoplysaccharide (LPS) were also reduced in spleenocytes. | ||
| Keywords | ||
| mice; diazinon; Immunotoxic response; female balb/C carbofuran; cypermethrine; insecticides | ||
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