Therapeutic Effects of Royal Jelly on Some Biochemical Parameters in Nephrotoxicity Induced by Carbon Tetrachloride (Ccl4) In Albino Rats. | ||
| Egyptian Academic Journal of Biological Sciences, B. Zoology | ||
| Article 19, Volume 13, Issue 1, June 2021, Pages 279-286 PDF (718.96 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsz.2021.184200 | ||
| Authors | ||
| Fatma Khairallah Ali1; Ahmed Mohamed2; Ahmed A. M. Hassan3 | ||
| 1Chemistry department, Benghazi University, Almarj city, Libya. | ||
| 2Biochemistry department, Faculty of Science, Al-Azhar University, Egypt | ||
| 3Biochemistry department, Faculty of Science, Al-Azhar University, Egypt. | ||
| Abstract | ||
| The present study was designed to determine the possible therapeutic effects of royal jelly against carbon tetrachloride (CCl4) induced oxidative stress and biochemical changes in the kidney of albino rats. A patch of 20 male albino rats averaged weights (190±10 g) at the beginning of the experiment were divided into 4 main groups according to the treatment and requirements of the experiment. The rats injected i.p. with CCl4 at a dose (1 mL/kg, 1:1 in olive oil) twice per week and received, via gavage, royal jelly at a dose (400 mg/kg b. wt) along the experimental period. Each group contains 5 rats that were sacrificed on the45 days from the start of the experiment. The results refer to a significant elevation of renal parameters (creatinine, blood Urea and Uric acid) on the 6th week in rats injected intraperitoneal with CCl4 as compared to the control groups. The administration of the royal jelly has beneficial and decrease side effects against the deleterious changes of CCl4. In conclusion, according to the results obtained the administration of the royal jelly provides considerable nephroprotective effects against intoxicated with CCl4 in male Wister albino rats by preventing oxidative stress through ROS scavenger and improvement in the former biochemical parameters. | ||
| Keywords | ||
| Carbon Tetrachloride (CCl4); nephrotoxicity; Kidney function; Royal Jelly | ||
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