SPECTROPHOTOMETRIC ESTIMATION OF METOCLOPRAMIDE HYDROCHLORIDE IN PHARMACEUTICAL PREPARATIONS | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Article 11, Volume 7, Issue 2, December 1998, Pages 80-85 PDF (2.37 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjps.1998.184804 | ||
| Authors | ||
| Sobhy EI-Adl* 1; Mohamed Baraka2; Osama El-Sabbagh2 | ||
| 1Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt. | ||
| 2Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt | ||
| Abstract | ||
| Two spectrophotometric methods were developed for the quantitative determination of metoclopramide hydrochloride and its dosage forms. The first method (method I) 1s based upon the interaction of the drug with 3-methyl benzothiazolinone-2-hydrazone (MBTH) in the presence of ferric chloride as an oxidizing agent, where a violet colour is formed that measured at A 555 nm in an aqueous media. The second method (method II) is based upon the interaction of the chloroformic extract of the drug free base, after alkalinization with 1,3-dinitrobenzene (DNB), where a charge-transfer complex product is formed that measured at 2 381 nm in chloroform The two proposed methods are accurate, sensitive, reproducible and applicable for the analysis of metoclopramide in the pure from and in its dosage forms (tablets and injections). The results obtained are compared with those of the titrimetric and UV measurement official B.P. 1998 method showing good agreement. | ||
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