IV -VITRO AND IN -VIVO AVAILABILITY OF NAPROXEN FROM TRANSPARENT OIL/ WATER GELS IN COMPARISON TO SOME CONVENTIONAL TOPICAL BASES | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Article 14, Volume 7, Issue 1, June 1998, Pages 105-110 PDF (3.99 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjps.1998.184820 | ||
| Author | ||
| Mohamed M EL-Sayed* | ||
| Dept. of Pharmaceutics, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt. | ||
| Abstract | ||
| Within the scope of evaluating transparent oil/water (TOW) gels as dermatological vehicles, the anti-inflammatory and analgesic agent Naproxen (NA) was incorporated in a transparent oil-water gel containing two emulsifying agents (Emulgin B3 and Cetiol HE), an oily liquid (isopropylpalmitate) and water. The release rate of NA from the TOW gel formulation through a cellophane membrane into phosphate buffer (pH 6) at 37°C was studied. The percutaneous absorption in rabbits was evaluated and compared with the absorption from a hydrogel and from a hydrophilic base formulation. The area under the curve and the Cmax values in plasma were significantly higher for the TOW gels in comparison with other formulations after single application. A good correlation was observed between the in-vitro and in-vivo data. | ||
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