PREPARATION AND EVALUATION OF IN VITRO DISSOLUTION CHARACTERISTICS OF SUSTAINED RELEASE METOPROLOL TARTRATE MICROCAPSULES | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Article 14, Volume 6, Issue 1, June 1997, Pages 99-104 PDF (3.71 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjps.1997.184960 | ||
| Author | ||
| Mohammed El-Sayed* | ||
| Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University , Egypt | ||
| Abstract | ||
| Metoprolol tartrate (MT) was encapsulated with Eudragit RS® by an emulsion-solvent evaporation method to develop a controlled release dosage form. This process was efficient, reproducible and not time consuming. Different release characteristics were obtained by changing the drug to polymer ratio and varying the percentage of aluminum tristearate incorporated in the encapsulation medium as a smoothing agent. In the presence of aluminum tristearate, the formed microcapsules were typically spherical and exhibited size distribution within a narrow range. High drug-to-polymer ratio resulted in increased microcapsule size and drug release rate. The microcapsules showed pH-independent dissolution behaviour. | ||
|
Statistics Article View: 97 PDF Download: 63 |
||
