EEECI OF LEAD EXPOSURE ON SOME SELECTED BIOCHEMICAL AND HAEMATOLOGICAL VARIABLES WITH SPECIAL REFERENCE TO REPRODUCTIVE TOXICITY IN FEMALE RABBITS. | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Article 18, Volume 5, Issue 2, December 1996, Pages 125-133 PDF (4.6 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjps.1996.185033 | ||
| Author | ||
| Usama Ali* | ||
| Department of Animal Reproduction and Artificial Insemination, National Research Center, Dokki, Egypt. | ||
| Abstract | ||
| The present study was designed to assess the effect of different levels of lead on ovarian activity and to elucidate some biochemical and haematological variables that can be associated with these levels. Immature female New Zealand rabbits were used, divided into four groups, each of six rabbits. Group I and II received low (5.4 mg/kg b. wt.) and high (10.8 mg / kg b.wt.) doses of lead acetate orally, respectively, daily for 5 days/week over a period of 8 weeks. Groups III and IV were kept as control. All groups (except group IV) were treated with 200 1.U pregnant mare serum gonadotrophin (PMSG) I/m, followed by i.m injection of 200 I.U human chorionic gonadotrophin (HCG), 48hrs after commencement of PMSG treatment. The results indicated that injection of PMSG followed by HCG had stimulated the ovarian activity of the control virgin does and elevated the total ovarian response, Metion rate and ovulation percentage. However, administration of low and high doses of lead acetate resulted in a significant decrease in total ovarian response, ovulation rate and ovulation percentage. Lead administration significantly decreased the levels of decteasereins and total lipids. However, a significant increase in the levels of triglycerides was obtained with low and high doses of lead. Cholesterol level was significantly increased with the high dose only. Estradiol-17β and progesterone were significantly decreased following oral administration of both doses of lead acetate. However, lead acetate administration resulted in a significant plasma of bolts were significantly increased with the low and high doses of lead acetate. However, haemoglobin concentration and response with profound changes in the biochemical, haematological and hormonal profiles | ||
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