Ebeid, M., Lashine, S., El-Adl, S., Abou-Kull, M. (1994). SYNTHESIS OF SOME PYRIMIDO-[1,6-a]- INDOLE OF POTENTIAL PHARMACOLOGICAL INTEREST. test, 3(2), 40-48. doi: 10.21608/zjps.1994.186442
Mohamed Ebeid; Sayed Lashine; Sobhy El-Adl; Mansour Abou-Kull. "SYNTHESIS OF SOME PYRIMIDO-[1,6-a]- INDOLE OF POTENTIAL PHARMACOLOGICAL INTEREST". test, 3, 2, 1994, 40-48. doi: 10.21608/zjps.1994.186442
Ebeid, M., Lashine, S., El-Adl, S., Abou-Kull, M. (1994). 'SYNTHESIS OF SOME PYRIMIDO-[1,6-a]- INDOLE OF POTENTIAL PHARMACOLOGICAL INTEREST', test, 3(2), pp. 40-48. doi: 10.21608/zjps.1994.186442
Ebeid, M., Lashine, S., El-Adl, S., Abou-Kull, M. SYNTHESIS OF SOME PYRIMIDO-[1,6-a]- INDOLE OF POTENTIAL PHARMACOLOGICAL INTEREST. test, 1994; 3(2): 40-48. doi: 10.21608/zjps.1994.186442

SYNTHESIS OF SOME PYRIMIDO-[1,6-a]- INDOLE OF POTENTIAL PHARMACOLOGICAL INTEREST

Zagazig Journal of Pharmaceutical Sciences
Article 5, Volume 3, Issue 2, December 1994, Pages 40-48    PDF (3.76 M)
Document Type: Original Article
DOI: 10.21608/zjps.1994.186442
Authors
Mohamed Ebeid* 1; Sayed Lashine2; Sobhy El-Adl3; Mansour Abou-Kull4
1Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt
2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt
3Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt
4Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt
Abstract
The synthesis of some pyrimido-[1,6-a]- indole derivatives is described. Addition of dicyanomethylideneindoline (I) to various isocyanates gave 2-alkyl-3-imino-1-oxo-1,2,3,5- tetrahydropyrimido-[1,6-a]- indole-4-carbonitrile lla-h. The corresponding enaminonitriles Illa-h were obtained from II by reduction with sodium borohydride. Compounds IV-VIl were also obtained. Preliminary pharmacological screening revealed antipyretic, antiinflammatory and analgesic activities.
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