Sharaf El-Din, N. (1994). STEREOSELECTIVE REACTION BETWEEN ACETANTHRANIL AND RACEMIC AMINE. test, 3(1), 35-39. doi: 10.21608/zjps.1994.186601
Nabaweya Sharaf El-Din. "STEREOSELECTIVE REACTION BETWEEN ACETANTHRANIL AND RACEMIC AMINE". test, 3, 1, 1994, 35-39. doi: 10.21608/zjps.1994.186601
Sharaf El-Din, N. (1994). 'STEREOSELECTIVE REACTION BETWEEN ACETANTHRANIL AND RACEMIC AMINE', test, 3(1), pp. 35-39. doi: 10.21608/zjps.1994.186601
Sharaf El-Din, N. STEREOSELECTIVE REACTION BETWEEN ACETANTHRANIL AND RACEMIC AMINE. test, 1994; 3(1): 35-39. doi: 10.21608/zjps.1994.186601

STEREOSELECTIVE REACTION BETWEEN ACETANTHRANIL AND RACEMIC AMINE

Zagazig Journal of Pharmaceutical Sciences
Article 5, Volume 3, Issue 1, June 1994, Pages 35-39    PDF (2 M)
Document Type: Original Article
DOI: 10.21608/zjps.1994.186601
Author
Nabaweya Sharaf El-Din*
Departments of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tanta, Tanta, Egypt
Abstract
Racemic amines 1-phenyl-ethylamine and 1-amino-2-propanol were found to undergo kinetic resolution in the stereoselective reaction with acetanthranil. The residual amines have optical rotation of (+) 5.2° and (+) 4.5° which correspond to optical purity of about 15.7% and 18% for 1-phenylethylamine and 1-amino-2-propanol, respectively. The effect of temperature, reaction time, solvent, concentration of amine and catalyst were examined on the kinetic resolution.
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