Synthesis and Antimicrobial Efficacy of Some Novel Heterocyclic Acetyl Istain Derivatives | ||
| Egyptian Journal of Chemistry | ||
| Article 38, Volume 65, Issue 1, January 2022, Pages 341-351 PDF (580.84 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.80431.3985 | ||
| Authors | ||
| Mahmoud Abuzeid1; Hemat Mohamed Dardeer* 2; Elghreep Elporaey3; Moustafa Fawzy2 | ||
| 1Chemistry Department, Faculty of science, South Valley University, Qena, Egypt | ||
| 2Depatement of Chemistry-Faculty of science -South Vally University | ||
| 3Departement of Chemistry, Faculty of Science, South Valley University | ||
| Abstract | ||
| A series of novel heterocyclic compounds containing N-acetyl isatine moiety were synthesized. Herein, reaction of N-acetyl isatine with water in the presence of a catalytic amount of glacial acetic acid, via a ring opening route, yielded 2-(2-acetamidophenyl)-2-oxoaceticacid,which acts as an adjustable precursor with different heteroaryl amines such as aniline, 2-amino pyridine, 5-amino-1,3,4-thiadiazole-2-thiol,phenylhydrazeine, for the preparation of different schiff bases. Furthermore, acetamide derivatives were prepared via the ring opening path of N-acetyl isatin, by the interaction of it with 2-aminomethylpyridine, aniline, and hydrazine hydrate. All prepared samples were confirmed by their spectral data such as FTIR, 1H-NMR, 13C-NMR, Mass spectrometry, and elemental analysis. Furthermore, all the obtained compounds were evaluated as antibacterial agents and gave promising results. | ||
| Keywords | ||
| N-acetylisatin; Schiff bases; NMR; azomethine group; antimicrobial | ||
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