Relationship between Hepcidin and Iron Deficiency Anemia in Helicobacter pylori Infected Patients | ||
| Egyptian Journal of Medical Microbiology | ||
| Article 3, Volume 30, Issue 3, July 2021, Pages 21-27 PDF (411.24 K) | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| Author | ||
| Emad Morad* | ||
| Lecturer of Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Egypt | ||
| Abstract | ||
| Background: Helicobacter pylori may be associated with unexplained iron-deficiency anemia (IDA). Hepcidin is an acute-phase reactant but its relation to H. pylori and IDA has not been elucidated. Objective: to investigate serum hepcidin in H. pylori infected patients and its role in IDA. Methodology: This study was performed on 70 patients infected by Helicobacter pylori. They were divided into two groups, group A: 35 H. pylori infected patients without iron deficiency anemia and group B: 35 H. pylori infected patients with iron deficiency anemia. Serum hepcidin was measured by ELISA in both groups while iron, ferritin and total iron binding capacity were estimated in group B. Results: Serum hepcidin was significantly higher in patients with H. pylori infection and iron deficiency anemia. However, non-significant correlation between hepcidin and both iron and ferritin were found. Conclusion: Helicobacter pylori could modulate serum hepcidin level in patients with iron deficiency anemia. | ||
| Keywords | ||
| Hepcidin; Iron Deficiency Anemia; Helicobacter Pylori | ||
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