Afifi, W., Oneam, T., Elfekky, O., Abdelhalim, W., Assar, E. (2021). Relationship Between Body Weight Serum Creatinine, Cystatin C in Early Prediction of Acute Kidney Injury in Critically Ill Neonates.. test, 16(1), 60-70. doi: 10.21608/geget.2021.187837
Wesam Afifi; Taghreed Oneam; Osama Elfekky; Waleed Abdelhalim; Effat H Assar. "Relationship Between Body Weight Serum Creatinine, Cystatin C in Early Prediction of Acute Kidney Injury in Critically Ill Neonates.". test, 16, 1, 2021, 60-70. doi: 10.21608/geget.2021.187837
Afifi, W., Oneam, T., Elfekky, O., Abdelhalim, W., Assar, E. (2021). 'Relationship Between Body Weight Serum Creatinine, Cystatin C in Early Prediction of Acute Kidney Injury in Critically Ill Neonates.', test, 16(1), pp. 60-70. doi: 10.21608/geget.2021.187837
Afifi, W., Oneam, T., Elfekky, O., Abdelhalim, W., Assar, E. Relationship Between Body Weight Serum Creatinine, Cystatin C in Early Prediction of Acute Kidney Injury in Critically Ill Neonates.. test, 2021; 16(1): 60-70. doi: 10.21608/geget.2021.187837

Relationship Between Body Weight Serum Creatinine, Cystatin C in Early Prediction of Acute Kidney Injury in Critically Ill Neonates.

GEGET
Article 4, Volume 16, Issue 1, June 2021, Pages 60-70    PDF (275.22 K)
Document Type: Original Article
DOI: 10.21608/geget.2021.187837
Authors
Wesam Afifi1; Taghreed Oneam* 1; Osama Elfekky1; Waleed Abdelhalim2; Effat H Assar1
1Department of Pediatrics, Benha University Hospital, Faculty of Medicine, Benha University, Benha, Egypt.
2Department of Clinical and chemical Pathology, Benha University, Egypt, Faculty of Medicine, Benha University, Egypt.
Abstract
Introduction: Neonatal Acute Kidney Injury (AKI) become a serious problem in critically ill neonates, serum creatinine level (SCr) which used to detect glomerular filtration rate has a lot of pitfalls, serum cystatin C level  (SCys C) is more accurate and with better advantages.
Aim of the Study: Our aim is to early detection of acute kidney injury in neonates especially low birth weight before any damage occur. 
Methods: This cross sectional study was conducted on 50 critically ill neonates randomly selected from the Neonatal Intensive Care Unit, Pediatric Department, in our University Hospitals. Detailed history, clinical examination, appropriate investigations were done. Plasma level of serum Cystatin C as well as SCr were done at the 1st and 3rd day of admission.
Results: Fifty infants were recruited into this study out of which complete data were available, the study was conducted on both term and preterm infants. The mean SCr level in AK I group in the 1st and 3rd day respectively was 0.56 and1.13, while serum cystatin level was 31.86 and48.67 respectively with significant P Value P ≤ 0.001, SCr had a significant correlation with weight (r = 0 .992; P < 0.001), whereas serum CysC had no correlation with the infant’s weight (r = 0.021; P = 0.884). There was no statistically significant difference in SCr and CysC between male and female infants. 
Conclusion: Serum Cystatin C is an earlier detector for AKI in critically ill neonates and un like serum creatinine has no significant correlation with birth weight. 
 
Keywords
Neonates; glomerular filtration rate; AKI; creatinine; Cystatin C
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