Farag, A., Abbas, S., Mikhael, A., Abdel Messeh, M. (1993). SYNTHESIS AND ANTIBACTERIAL EVALUATION OF CERTAIN 1,2,4- TRIAZOLE AND THIAZOLID INONE DERIVATIVES. test, 2(1), 108-119. doi: 10.21608/zjps.1993.188994
Awatef Farag; Safinaz Abbas; Anwar Mikhael; Mona Abdel Messeh. "SYNTHESIS AND ANTIBACTERIAL EVALUATION OF CERTAIN 1,2,4- TRIAZOLE AND THIAZOLID INONE DERIVATIVES". test, 2, 1, 1993, 108-119. doi: 10.21608/zjps.1993.188994
Farag, A., Abbas, S., Mikhael, A., Abdel Messeh, M. (1993). 'SYNTHESIS AND ANTIBACTERIAL EVALUATION OF CERTAIN 1,2,4- TRIAZOLE AND THIAZOLID INONE DERIVATIVES', test, 2(1), pp. 108-119. doi: 10.21608/zjps.1993.188994
Farag, A., Abbas, S., Mikhael, A., Abdel Messeh, M. SYNTHESIS AND ANTIBACTERIAL EVALUATION OF CERTAIN 1,2,4- TRIAZOLE AND THIAZOLID INONE DERIVATIVES. test, 1993; 2(1): 108-119. doi: 10.21608/zjps.1993.188994

SYNTHESIS AND ANTIBACTERIAL EVALUATION OF CERTAIN 1,2,4- TRIAZOLE AND THIAZOLID INONE DERIVATIVES

Zagazig Journal of Pharmaceutical Sciences
Article 11, Volume 2, Issue 1, June 1993, Pages 108-119    PDF (4.52 M)
Document Type: Original Article
DOI: 10.21608/zjps.1993.188994
Authors
Awatef Farag* 1; Safinaz Abbas1; Anwar Mikhael2; Mona Abdel Messeh2
1Pharmaceutical Chemistry Department, faculty of Pharmacy, Cairo University, Cairo, Egypt
2BACTERIOLOGY DEPARTMENT, FACULTY OF MEDICINE, CAIRO UNIVERSITY.
Abstract
The synthesis of certain 3 -  (4- chloro - 3,5 - đimethyl - phenoxy ) methyl  4-alkyl or aryl -5 mercapto - 1,2,4 - triazoles ( 5a - e) is described. The preparation of these triazoles was achieved by the cyclization of the corresponding thiosemicarbazides (Af- i) using piperidine in refluxing ethanol. Also , series of thioethers (6a,b) and (7a-g) were obtained by reacting (5) with different halo- compounds .The thiaz olidinone derivatives (8 a - d ) were prepared by reacting (4f - j) with ethyl bromoacetate .The new compounds were proved by elemental analysis, ir and 1H- nmr. The antibacterial activity was carried out for eight representative compounds .
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