Mohamed, M., Ahmed, A., El-Maraghy, N., Nawrath, H., El-Gharabawy, A. (1993). MONENSIN ENHANCES DIGOXIN-INDUCED ARRHYTHMIAS IN GUINEA-PIGS. test, 2(1), 150-160. doi: 10.21608/zjps.1993.188999
Mohamed Mohamed; Ahmed Ahmed; Nabila El-Maraghy; H Nawrath; Atef El-Gharabawy. "MONENSIN ENHANCES DIGOXIN-INDUCED ARRHYTHMIAS IN GUINEA-PIGS". test, 2, 1, 1993, 150-160. doi: 10.21608/zjps.1993.188999
Mohamed, M., Ahmed, A., El-Maraghy, N., Nawrath, H., El-Gharabawy, A. (1993). 'MONENSIN ENHANCES DIGOXIN-INDUCED ARRHYTHMIAS IN GUINEA-PIGS', test, 2(1), pp. 150-160. doi: 10.21608/zjps.1993.188999
Mohamed, M., Ahmed, A., El-Maraghy, N., Nawrath, H., El-Gharabawy, A. MONENSIN ENHANCES DIGOXIN-INDUCED ARRHYTHMIAS IN GUINEA-PIGS. test, 1993; 2(1): 150-160. doi: 10.21608/zjps.1993.188999

MONENSIN ENHANCES DIGOXIN-INDUCED ARRHYTHMIAS IN GUINEA-PIGS

Zagazig Journal of Pharmaceutical Sciences
Article 15, Volume 2, Issue 1, June 1993, Pages 150-160    PDF (3.53 M)
Document Type: Original Article
DOI: 10.21608/zjps.1993.188999
Authors
Mohamed Mohamed* 1; Ahmed Ahmed1; Nabila El-Maraghy2; H Nawrath3; Atef El-Gharabawy4
1Department of Pharmacology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
2Department of Pharmacology, Faculty of Pharmacy, Zagazig University, Egypt
3Dept. of Pharmacology, Faculty of Medicine, University of Mainz, Germany
4Dept. of Pharmacology, Faculty of Pharmacy, Zagazig University, Egypt
Abstract
Effects of pretreatment with monensin (150 ug/kg), atenolol (0.3 mg/kg), atenolol plus monensin, verapamil (0.38 mg/kg), verapamil plus monensin, glibenclamide(0.38 mg/kg) and glibenclamide plus monensin on the dose of digoxin required to induce premature ventricular contractions (PVCS) in anaesthetized guinea-pigs were studied. Monensin reduced while atenolol increased the dose of digoxin required to produce PVCS. Atenolol plus monensin increased the dose of digoxin required to produce PVCS in presence of monensin alone. Verapamil reduces the arrhythmogenic effect of monensin on digoxin. Glibenclamide antagonises the effect of monensin on digoxin induced PVCS.
From the present data it could be concluded that, monensin enhances digoxin-induced arrhythmias in guinea-pigs. The enhancement of arrhythmias in presence of monensin may be due to catecholamine release by monensin and or may be due to the decrease of action potential duration which in part result from opening of ATP dependent K+ channels in guinea pig ventricular muscle these channels, which blocked by glibenclamide.
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