PERIPAPILLARY RETINAL NERVE FIBER LAYER THICKNESS CHANGES IN DIABETIC PATIENTS AFTER PANRETINAL PHOTOCOAGULATION | ||
| Egyptian Journal of Clinical Ophthalmology | ||
| Article 2, Volume 4, Issue 1, June 2021, Pages 15-22 PDF (409.53 K) | ||
| Document Type: Original articles: include clinical trials, interventional research, Basic researches and clinically relevant laboratory investigations | ||
| DOI: 10.21608/ejco.2021.189054 | ||
| Authors | ||
| Tamam, K.1; Mohamed, M.1; Elmoddather, M.1; Sayed, Kh.2 | ||
| 1Ophthalmology dept., Faculty of Medicine, AL-Azhar Univ., Assuit, Egypt | ||
| 2Ophthalmology dept., Faculty of Medicine, Sohag Univ., Sohag, Egypt | ||
| Abstract | ||
| Aim of the work: This study aimed to assess the effect of Panretinal photocoagulation (PRP) on the peripapillary Retinal Nerve Fiber (RNFL) thickness in diabetic patients using Optical Coherence Tomography Angiography. Methods: A prospective study was conducted on 100 eyes of 62 patients who had severe non-proliferative (SNPDR) or proliferative diabetic retinopathy (PDR) and underwent PRP treatment. The study population underwent 4.5×4.5 MM scans centered on the optic nerve head using Optical Coherence Tomography Angiography (OCTA) (RTVue XR Avanti Optovue, Fremont, CA) for measuring the peripapillary RNFL thickness before and after PRP by 2 months and 6 months. Results: Mean age of the study population was 49.85± 8.26 years (25-64 years). There was a significant increase in thickness of the nasal, temporal, superior and inferior peripapillary RNFL from baseline to 2 months post-PRP (all P value <0.05) and then decreased significantly from 2 months to 6 months (all P value <0.05). However, the thickness decreased significantly to amount less than baseline after 6 months for superior and inferior quadrants (P value <0.05) and decreased insignificantly for nasal and temporal quadrants (P value > 0.05). Conclusions: Peripapillary RNFL thickness at 6 months has decreased post-PRP, suggesting that PRP had neuronal insult. | ||
| Keywords | ||
| Diabetic retinopathy; proliferative; photocoagulation; Optical Coherence; Angiography | ||
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