Elsayed, A., Esmail, Y., Assar, E., Kora, M. (2021). Relation between urine soluble trigerring receptor expressed on myeloid cells (sTERM-1 ) and blood culture for diagnosis of late onset sepsis in neonates. test, 6(4), 169-175. doi: 10.21608/bjas.2021.189910
A.S. Elsayed; Y.M. Esmail; E.H. Assar; M.I. Kora. "Relation between urine soluble trigerring receptor expressed on myeloid cells (sTERM-1 ) and blood culture for diagnosis of late onset sepsis in neonates". test, 6, 4, 2021, 169-175. doi: 10.21608/bjas.2021.189910
Elsayed, A., Esmail, Y., Assar, E., Kora, M. (2021). 'Relation between urine soluble trigerring receptor expressed on myeloid cells (sTERM-1 ) and blood culture for diagnosis of late onset sepsis in neonates', test, 6(4), pp. 169-175. doi: 10.21608/bjas.2021.189910
Elsayed, A., Esmail, Y., Assar, E., Kora, M. Relation between urine soluble trigerring receptor expressed on myeloid cells (sTERM-1 ) and blood culture for diagnosis of late onset sepsis in neonates. test, 2021; 6(4): 169-175. doi: 10.21608/bjas.2021.189910

Relation between urine soluble trigerring receptor expressed on myeloid cells (sTERM-1 ) and blood culture for diagnosis of late onset sepsis in neonates

Benha Journal of Applied Sciences
Article 26, Volume 6, Issue 4, August 2021, Pages 169-175    PDF (795.81 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2021.189910
Authors
A.S. Elsayed1; Y.M. Esmail2; E.H. Assar1; M.I. Kora1
1Pediatrics, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
2Clinical pathology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
Abstract
Background: The sepsis gold standard is to identify the blood-growing agent. However, the production of a pathogen is not feasible for various reasons, even in the finest facilities. The purpose of this research was to identify the relationship between myeloid cell myeloid cell (STREM-1)-soluble trigger receptor and blood culture to diagnose late onset septicism. Methods: 100 cases from newborn intensive care units (NICU) divided into the following categories were included in this comparative case/check research. Group 1: 60 patients with positive blood culture sepsis included, Group 2: 40 patients with negative blood culture sepsis and Group 3: 100 patients with healthy neonate. All of the newborns included have been submitted to comprehensive history, clinical and laboratory tests of CBC, CRP and urine sTREM-1. Outcome: 60 (60%) instances of positive blood culture were 83,28 ± 6,17 pg/ml of the mean uTREM1, compared to 51,19 ± 19,47 pg/ml of the negative crop group and 78,22 ± 0,25 pg/ml of the checks, p <0,001. ROC curve was used to evaluate uTREM's diagnostic results for positive blood culture, uTREM1 was able to forecast positive AUC=0.999 (p < 0.001), CI (0.990-1). The sensitivity was 98.33 percent at a cut-off of > 72 pg/ml, the specificity was 95 percent, 96.7 percent and 97.4 percent. Conclusion: Our findings support the use of uTREM-1 in newborn sepsis as a potentially simple and reliable diagnostic while awaiting results and results in culture.
Keywords
sTERM-1; blood culture; sepsis; neonates
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