Molecular dual actions of hsa-miRNA and v-miRNA in oncogenic EBV | ||
| Microbial Biosystems | ||
| Article 2, Volume 6, Issue 1, June 2021, Pages 1-10 PDF (672.25 K) | ||
| Document Type: Reviews | ||
| DOI: 10.21608/mb.2021.87024.1034 | ||
| Authors | ||
| Rezhna Kheder Ali1; Sazan Qader Maulud2; Paywast Jamal Jalal3; Jivan Qasim Ahmed* 4 | ||
| 1Department of Biology, College of Education, Salahaddin University-Erbil, Kurdistan Region of Iraq | ||
| 21.Department of Biology, College of Education, Salahaddin University-Erbil, Kurdistan Region of Iraq 2.Department of Medical Labrotary Science, College of Science, Knowledge University, Kirkuk Road, 44001,Erbil,Iraq | ||
| 3Department of Biology, College of Science, University of Sulaimani, Kurdistan Region of Iraq | ||
| 4Department of pathology and Microbiology, University of Duhok, Kurdistan Region, Iraq. | ||
| Abstract | ||
| Viruses are one of the main reasons that cause healthy cells to proliferate and become cancerous. Several viruses have been identified as causative factors for various forms of cancer. Tumor occurrence can be caused by viral oncoprotein activity, persistent infection or inflammation. The molecular process is still complicated to be understood. In recent decades, Homo sapiens cell microRNA (hsa-miRNA) has been discovered by small non-coding RNAs that affect post-transcriptional gene expression. hsa-miRNA is a key control factor for several key biological processes and has a much greater impact on the target gene group. even though they occupy a small part of the genome, they play a great role in the development of cancer. Several viruses produce this tiny RNA, which can regulate their gene expression or affect the host's gene expression. A new hypothesis is that Epstein-Barr virus (EBV) is the first cancer causing virus that is found to produce microRNAs (v-miRNAs). In addition, evidence shows that miRNA encoded by EBV contributes to the occurrence and progression of EBV-related malignancies. Generally, these compounds reduce messenger RNA (mRNA) instability, such as genes that regulate tumorigenesis mechanisms like inflammation, cell cycle control, stress response, differentiation, apoptosis, invasion, and immune pathways. Therefore, EBV-miRNAs are important in the complex interaction between host, virus and EBV tumorigenesis. In terms of malignant tumors, the combinatorial process behind EBV-miRNA still needs further study. In this article, we will introduce EBV-miRNA, including the cellular processes affected by the virus, and their ability to promote cancer. | ||
| Keywords | ||
| EBV; Oncovirus; viral miRNA; host miRNA | ||
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