EXPERIMENTAL STUDY OF HYPOTHYROIDISM IN RATS 2- HISTOPATHOLOGICAL AND MORPHOMETRICAL CHANGES IN THE LIVE | ||
| Assiut Veterinary Medical Journal | ||
| Article 17, Volume 12.1, Issue 23, May 1984, Pages 130-134 PDF (1.45 M) | ||
| Document Type: Research article | ||
| DOI: 10.21608/avmj.1984.190907 | ||
| Authors | ||
| M.K. IBRAHIM; M.S. YOUSSEF | ||
| Abstract | ||
| The present study was designed to investigate the effect of experi mental hypothyroidism induced by subcutaneous injection of methyl thiouracil (MTU) on the morphological and morphometrical changes in the liver of the rat. Fifty rats were used in this experiment. They were divided into four groups A,B,C and D and injected by subcutaneous route with methylthiouracil at a dose level of 10, 0.5, 0.2 and 0.1 mg. per kg. body weight respectively. In addition, a fifth group (E) of 10 rats was used as a control. The histopatholo gical examination revealed pronounced congestion together with focal degenerative changes. The morphometrical changes were char acterized by an increase in the nuclear diameter of hepatic cells in the first two groups. | ||
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