Green synthesis: Antimicrobial activity of novel benzothiazole-bearing coumarin derivatives and their fluorescence properties | ||
| Egyptian Journal of Chemistry | ||
| Article 67, Volume 65, Issue 2, February 2022, Pages 679-686 PDF (668.13 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.91887.4365 | ||
| Authors | ||
| Nadia Hanafy Metwally* 1; Galal El-gemeie2; Fatma Gomaa fahmy3 | ||
| 1Chemistry, Faculty of Science, Cairo University, Giza, Egypt | ||
| 2Chemistry department, Faculty of Science, Helwan University. | ||
| 3Chemistry department, Faculty of Science, Cairo University | ||
| Abstract | ||
| A new benzothiazole derivatives 4a-f were prepared by the reaction of2-cyanomethylbenzothiazole 1 with 2-hydroxy-5-(aryldiazenyl)benzaldehyde derivatives 2a-f under conventional method in ethanol containing few drops of triethylamine. The previous reaction was reinvestigated at room temperature using grindstone techniques in the presence of sodium hydroxide. The compounds 4a-f transformed into benzothiazole-bearing coumarin derivatives 5a-f by refluxing in dioxane with few drops of conc. hydrochloric acid. The structure of the newly synthesized compounds 4a-f and 5a-f was established by spectral data. The compounds 5a-f showed fluorescence properties as well as antimicrobial activity. | ||
| Keywords | ||
| 2-cyanomethylbenzothiazole; grindstone method; coumarin derivatives; antimicrobial activity; fluorescence properties | ||
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