Synthesis and Studying of the Biological Activity of Some New Coumarin-3-carboxylic Acid Heterocyclic Derivatives | ||
| Egyptian Journal of Chemistry | ||
| Article 5, Volume 65, Issue 2, February 2022, Pages 35-40 PDF (440.8 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.36058.2745 | ||
| Authors | ||
| Alaa Fadihl Razaq; Majed Jari Mohammed | ||
| Department of Chemistry, Faculty of Science, University of Kufa, Najaf, Iraq | ||
| Abstract | ||
| This study includes the synthesis of a few different coumarin-3-carboxylic acid derivatives of 1,2,3-triazole and triazoline as a starting material. The first step involves the formation of compound (a) in absolute ethanol through the reaction of coumarin-3-carboxylic acid to thiosemicarbazide. Then compound (a) reacts with chloroacetyl chloride in the presence of triethylamine for compound forming (b). Azide derivative compound (c) was prepared with sodium azide in DMF by compound reaction (b). The heterocyclic compounds 1,2,3-triazole and triazoline derivatives (Mch1, Mch2, d, e , and f) were prepared with some unsaturated compounds such as propergyl bromide, cinnamic acid, and maleic anhydride in DMF from the reaction of compound (c). All compounds were identified by FT-IR, 1H-NMR spectrum, and C.H.N.S elemental analysis. The heterocyclic compounds were tested as an antibacterial activity with certain microorganism types. They showed good antimicrobial activity towards the investigated specific microorganisms. | ||
| Keywords | ||
| Keywords: Coumarin; Heterocyclic compounds; 1; 2; 3-Triazole; Antimicrobial activity | ||
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