COMPARATIVE SYUDY ON THE EFFECT OF SINGLE AND REPEATED DOSES OF THIACPHENICOL AND CHLORAMPHENICOL IN RATS | ||
| Assiut Veterinary Medical Journal | ||
| Article 7, Volume 4.2, Issue 8, May 1977, Pages 65-78 PDF (5.9 M) | ||
| Document Type: Research article | ||
| DOI: 10.21608/avmj.1977.193211 | ||
| Authors | ||
| I.M. SHEHATA; R.E.M. DOGHAIM; F.I. FARKOUH | ||
| Pathology and Parasitology Department. Faculty of Veterinary Medicine, University Cairo. | ||
| Abstract | ||
| Thiamphenicol and chloramphenicol are known as two related drugs. However, it was claimed that the latter is more toxic. Evaluation of the effect of single and repeated doses on liver. Spleen, bone marrow in addition to mus cles at the site of injection was adopted. In addition, blood picture, serum glutamic oxal acetic transaminase (SGOT) and serum glutamic pyruvic transaminase ( SGPT ) were performed. Histopathological examination revealed that liver is the most affected organ with single and rep < /strong>eated doses of both drugs accomp < /strong>anied by increased level of SGOT and SGPT.Both drugs have the same drastic effect on liver and ser um enzymes together with hemopoeitic organs. The difference lies only in the extent of cha nge induced by single or more particular, repeated doses of either drugs. | ||
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